The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

In the past decade, islet inflammation has emerged as a contributor to the loss of functional β
cell mass in both type 1 (T1D) and type 2 diabetes (T2D). Evidence supports the idea that …

Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion
from pancreatic β‐cells. Inflammatory cytokines, including tumour necrosis factor‐α (TNF‐α) …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

Evidence in support of the concept of local pancreatic islet inflammation as a mechanism of
β cell failure in type 2 diabetes is accumulating. Observations in human islets from type 2 …

Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to
type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local …

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

Decreases in both mass and secretory function of insulin-producing β-cells contribute to the
pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes …

Islets produce a variety of cytokines and chemokines in response to physiologic and
pathologic stimulation by nutrients. The cellular source of these inflammatory mediators …

Chronic systemic inflammation is a hallmark feature of obesity and type 2 diabetes. Both
resident and recruited islet macrophages contribute to the proinflammatory milieu of the …