[HTML][HTML] Next-generation sequencing for infectious disease diagnosis and management: a report of the Association for Molecular Pathology

MI Lefterova, CJ Suarez, N Banaei… - The Journal of Molecular …, 2015 - Elsevier
Next-generation sequencing (NGS) technologies are increasingly being used for diagnosis
and monitoring of infectious diseases. Herein, we review the application of NGS in clinical …

Making the leap from research laboratory to clinic: challenges and opportunities for next-generation sequencing in infectious disease diagnostics

B Goldberg, H Sichtig, C Geyer, N Ledeboer… - MBio, 2015 - Am Soc Microbiol
Next-generation DNA sequencing (NGS) has progressed enormously over the past decade,
transforming genomic analysis and opening up many new opportunities for applications in …

Next-generation sequencing in clinical microbiology: are we there yet?

SL Mitchell, PJ Simner - Clinics in laboratory medicine, 2019 - labmed.theclinics.com
Next-generation sequencing (NGS) is a method that allows for high-throughput, massively
parallel sequencing of thousands to billions of DNA fragments independently and …

[HTML][HTML] Clinical detection and characterization of bacterial pathogens in the genomics era

PE Fournier, G Dubourg, D Raoult - Genome medicine, 2014 - Springer
The availability of genome sequences obtained using next-generation sequencing (NGS)
has revolutionized the field of infectious diseases. Indeed, more than 38,000 bacterial and …

Validation of metagenomic next-generation sequencing tests for universal pathogen detection

R Schlaberg, CY Chiu, S Miller… - … of Pathology and …, 2017 - meridian.allenpress.com
Context.—Metagenomic sequencing can be used for detection of any pathogens using
unbiased, shotgun next-generation sequencing (NGS), without the need for sequence …

[HTML][HTML] Next generation and other sequencing technologies in diagnostic microbiology and infectious diseases

EE Hilt, P Ferrieri - Genes, 2022 - mdpi.com
Next-generation sequencing (NGS) technologies have become increasingly available for
use in the clinical microbiology diagnostic environment. There are three main applications of …

Understanding the promises and hurdles of metagenomic next-generation sequencing as a diagnostic tool for infectious diseases

PJ Simner, S Miller, KC Carroll - Clinical Infectious Diseases, 2018 - academic.oup.com
Agnostic metagenomic next-generation sequencing (mNGS) has emerged as a promising
single, universal pathogen detection method for infectious disease diagnostics. This …

From the pipeline to the bedside: advances and challenges in clinical metagenomics

A Dulanto Chiang, JP Dekker - The Journal of infectious …, 2020 - academic.oup.com
Next-generation sequencing (NGS) technologies have revolutionized multiple areas in the
field of infectious diseases, from pathogen discovery to characterization of genes mediating …

Next generation sequencing and bioinformatics methodologies for infectious disease research and public health: approaches, applications, and considerations for …

I Maljkovic Berry, MC Melendrez… - The Journal of …, 2020 - academic.oup.com
Next generation sequencing (NGS) combined with bioinformatics has successfully been
used in a vast array of analyses for infectious disease research of public health relevance …

Clinical metagenomic next-generation sequencing for pathogen detection

W Gu, S Miller, CY Chiu - Annual Review of Pathology …, 2019 - annualreviews.org
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive
approach for pathogen detection. The cost of high-throughput or next-generation …