Background: FcγRIIb is the only inhibitory IgG receptor, which is divided into three subtypes
of FcγRIIb1, FcγRIIb2 and FcγRIIb3. It is mainly responsible for the immune balance in vivo …

An immune response needs to be tightly regulated to prevent excessive inflammation, which
may result in the destruction of healthy tissues. At the molecular level, the strength of an …

The Fc gamma receptor IIB (FcγRIIB/CD32B) was generated million years ago during
evolution. It is the sole inhibitory receptor for IgG, and has long been associated with the …

Cell-surface Fcγ receptors mediate innate and adaptive immune responses. Human Fcγ
receptor I (hFcγRI) binds IgGs with high affinity and is the only Fcγ receptor that can …

IgG immune complexes are of central importance in the humoral immune system and
strongly implicated in the pathogenesis of hematologic and rheumatic autoimmune …

We are investigating the interactions of recombinant human IgG antibodies with Fc receptors
to enable selection of a constant region giving minimal depletion of antigen-bearing cells …

Antibodies are secreted to recognize and in some cases directly neutralize pathogens.
Another important means by which they are essential components of the immune system is …

FcγRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in
controlling responses to infection, and reduced expression or function predisposes to …

Human monocytes/macrophages express three classes of receptors for IgG: FcγRI, FcγRII,
and FcγRIII. The expression and function of these receptors has been extensively studied …

The monoclonal antibody SM201 specifically recognizes the human inhibitory FcγRIIB
without showing cross-reactivity to the related but activating FcγRIIA. The epitope …