Decoding pseudouridine: an emerging target for therapeutic development
Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …
Pseudouridine in a new era of RNA modifications
Pseudouridine (Ψ) was among the first post-transcriptional modifications discovered and is
overall one of the most abundant [1]. It is present in a wide range of cellular RNAs and is …
overall one of the most abundant [1]. It is present in a wide range of cellular RNAs and is …
RNA pseudouridylation in physiology and medicine: for better and for worse
M Penzo, AN Guerrieri, F Zacchini, D Treré… - Genes, 2017 - mdpi.com
Pseudouridine is the most abundant modification found in RNA. Today, thanks to next-
generation sequencing techniques used in the detection of RNA modifications …
generation sequencing techniques used in the detection of RNA modifications …
Regulation and function of RNA pseudouridylation in human cells
EK Borchardt, NM Martinez… - Annual review of …, 2020 - annualreviews.org
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …
Pseudouridylation meets next-generation sequencing
M Zaringhalam, FN Papavasiliou - Methods, 2016 - Elsevier
The isomerization of uridine to pseudouridine (Ψ), known as pseudouridylation, is the most
abundant post-transcriptional modification of stable RNAs. Due to technical limitations in …
abundant post-transcriptional modification of stable RNAs. Due to technical limitations in …
Pseudouridine: the fifth RNA nucleotide with renewed interests
Highlights•Ψ is overall the most abundant RNA modification.•Ψ is wide-spread in ncRNAs
and plays important roles for their functions.•Ψ can be induced upon stress …
and plays important roles for their functions.•Ψ can be induced upon stress …
Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome
Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification, yet little is
known about its prevalence, mechanism and function in mRNA. Here, we performed …
known about its prevalence, mechanism and function in mRNA. Here, we performed …
Quantitative profiling of pseudouridylation landscape in the human transcriptome
Pseudouridine (Ψ) is an abundant post-transcriptional RNA modification in ncRNA and
mRNA. However, stoichiometric measurement of individual Ψ sites in human transcriptome …
mRNA. However, stoichiometric measurement of individual Ψ sites in human transcriptome …
mRNA structure determines modification by pseudouridine synthase 1
Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA–RNA and RNA–
protein interactions that affect gene expression. Messenger RNA pseudouridylation was …
protein interactions that affect gene expression. Messenger RNA pseudouridylation was …
Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome
Pseudouridine (Ψ) is one of the most abundant modifications in cellular RNA. However, its
function remains elusive, mainly due to the lack of highly sensitive and accurate detection …
function remains elusive, mainly due to the lack of highly sensitive and accurate detection …