Improving interventional causal predictions in regulatory risk assessment

LA Cox Jr - Critical Reviews in Toxicology, 2023 - Taylor & Francis
In 2022, the US EPA published an important risk assessment concluding that “Compared to
the current annual standard, meeting a revised annual standard with a lower level is …

Miscommunicating risk, uncertainty, and causation: Fine particulate air pollution and mortality risk as an example

L Anthony (Tony) Cox - Risk Analysis: An International Journal, 2012 - Wiley Online Library
A recent paper in this journal (Fann et al., 2012) estimated that “about 80,000 premature
mortalities would be avoided by lowering PM2. 5 levels to 5 μg/m3 nationwide” and that …

How Do Exposure Estimation Errors Affect Estimated Exposure-Response Relations?

LA Cox Jr, LA Cox Jr - Quantitative risk analysis of air pollution health …, 2021 - Springer
Associations between fine particulate matter (PM2. 5) exposure concentrations and a wide
variety of undesirable outcomes are routinely reported. Adverse outcomes associated with …

Methods for estimating the exposure-response curve to inform the new safety standards for fine particulate matter

M Cork, D Mork, F Dominici - arXiv preprint arXiv:2306.03011, 2023 - arxiv.org
Exposure to fine particulate matter ($ PM_ {2.5} $) poses significant health risks and
accurately determining the shape of the relationship between $ PM_ {2.5} $ and health …

Characterizing the Long‐Term PM2.5 Concentration‐Response Function: Comparing the Strengths and Weaknesses of Research Synthesis Approaches

N Fann, EA Gilmore, K Walker - Risk Analysis, 2016 - Wiley Online Library
The magnitude, shape, and degree of certainty in the association between long‐term
population exposure to ambient fine particulate matter (PM2. 5) and the risk of premature …

[PDF][PDF] Response to Cox Letter:“Miscommunicating Risk, Uncertainty, and Causation: Fine Particulate Air Pollution and Mortality Risk as an Example”

N Fann, AD Lamson, SC Anenberg, K Wesson… - Risk Analysis, 2012 - academia.edu
In his critique of our article, Dr. Cox makes a strong assertion: my co-authors and I have
miscommunicated the level of uncertainty in our analysis by failing to account explicitly for …

Do causal concentration–response functions exist? A critical review of associational and causal relations between fine particulate matter and mortality

LA Cox Jr - Critical reviews in toxicology, 2017 - Taylor & Francis
Abstract Concentration–response (C–R) functions relating concentrations of pollutants in
ambient air to mortality risks or other adverse health effects provide the basis for many public …

[HTML][HTML] Commentary: Using potential outcomes causal methods to assess whether reductions in PM2. 5 result in decreased mortality

JE Goodman, W Li, LA Cox Jr - Global Epidemiology, 2021 - Elsevier
Causal inference regarding exposures to ambient fine particulate matter (PM 2.5) and
mortality estimated from observational studies is limited by confounding, among other …

Caveats for causal interpretations of linear regression coefficients for fine particulate (PM2. 5) air pollution health effects

LA Cox Jr - Risk analysis, 2013 - Wiley Online Library
Recent linear regression analyses have concluded that decreasing levels of fine particulate
matter (PM2. 5) air pollution have increased life expectancy in the United States. These …

Rethinking the meaning of concentration–response functions and the estimated burden of adverse health effects attributed to exposure concentrations

LA Cox Jr - Risk Analysis, 2016 - Wiley Online Library
Four articles by Anenberg et al., Fann et al., Shin et al., and Smith contribute valuable
perspectives and syntheses to a large and growing literature that estimates the burden of …