[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
[HTML][HTML] Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
RIG‐I‐like receptors: cytoplasmic sensors for non‐self RNA
H Kato, K Takahasi, T Fujita - Immunological reviews, 2011 - Wiley Online Library
Viral infection results in the generation of non‐self RNA species in the cells, which is
recognized by retinoic acid inducible gene‐I‐like receptors (RLRs), and initiates innate …
recognized by retinoic acid inducible gene‐I‐like receptors (RLRs), and initiates innate …
Regulation of RLR-mediated innate immune signaling–it is all about keeping the balance
K Eisenächer, A Krug - European journal of cell biology, 2012 - Elsevier
The current view of cytoplasmic RNA-mediated innate immune signaling involves the
differential activation of the RNA helicases retinoic acid-inducible gene 1 (RIG-I), melanoma …
differential activation of the RNA helicases retinoic acid-inducible gene 1 (RIG-I), melanoma …
RNA recognition and signal transduction by RIG‐I‐like receptors
M Yoneyama, T Fujita - Immunological reviews, 2009 - Wiley Online Library
Viral infection is detected by cellular sensor molecules as foreign nucleic acids and initiates
innate antiviral responses, including the activation of proinflammatory cytokines and type I …
innate antiviral responses, including the activation of proinflammatory cytokines and type I …
Viral RNA detection by RIG-I-like receptors
M Yoneyama, K Onomoto, M Jogi, T Akaboshi… - Current opinion in …, 2015 - Elsevier
Highlights•RLRs recognize viral non-self RNA with differential molecular machinery.•
Cytoplasmic aggregates containing RLRs are formed in response to viral dsRNA.•Ubiquitin …
Cytoplasmic aggregates containing RLRs are formed in response to viral dsRNA.•Ubiquitin …
[HTML][HTML] Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors
C Lässig, KP Hopfner - Journal of Biological Chemistry, 2017 - ASBMB
RIG-I-like receptors (RLRs) are cytosolic innate immune sensors that detect pathogenic RNA
and induce a systemic antiviral response. During the last decade, many studies focused on …
and induce a systemic antiviral response. During the last decade, many studies focused on …
Sensing viral invasion by RIG-I like receptors
JS Yoo, H Kato, T Fujita - Current opinion in microbiology, 2014 - Elsevier
Highlights•RLRs are viral sensors that recognize cytoplasmic non-self RNA.•IFN signaling is
induced by RLRs through unique and common sensing mechanisms.•Biochemical …
induced by RLRs through unique and common sensing mechanisms.•Biochemical …
Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity
Retinoic acid–inducible gene (RIG)-I–like receptors (RLRs) are cytosolic RNA helicases that
sense viral RNA and trigger signaling pathways that induce the production of type I …
sense viral RNA and trigger signaling pathways that induce the production of type I …
RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity
M Yoneyama, T Fujita - Cytokine & growth factor reviews, 2007 - Elsevier
Viral infection is detected by cellular sensors as foreign nucleic acid and initiates innate
antiviral responses, including the activation of type I interferon (IFN) and proinflammatory …
antiviral responses, including the activation of type I interferon (IFN) and proinflammatory …