Inflammasomes are multi-protein macromolecular complexes that typically comprise of three
units, a sensor, an adaptor and procaspase-1. The assembly of each inflammasome is …

Neuroinflammation is initiated with an aberrant innate immune response in the central
nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are …

Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate
inflammation activation in the innate immune system in response to pathogens and to host …

Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …

Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …

Primary progressive multiple sclerosis is a poorly understood disease entity with no specific
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …

Summary While interleukin (IL)-1β plays an important role in combating the invading
pathogen as part of the innate immune response, its dysregulation is responsible for a …

Inflammasomes are supramolecular protein complexes implicated in the detection of
pathogens or danger-associated molecules and are responsible for mounting the first line of …

In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

The inflammasome is a molecular platform formed by activation of an innate immune pattern
recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC …