Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in
Alzheimer's disease (AD) dementia and is a common finding at autopsy. The APOE ε4 allele …

Background and purpose Cerebral amyloid angiopathy (CAA) is common in the ageing
brain and is associated with dementia and lobar intracerebral haemorrhage. We …

Introduction Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of
amyloid-β (Aβ) in brain vessels and is a main cause of lobar intracerebral hemorrhage (ICH) …

Alzheimer's disease (AD) and related dementias are a major public health challenge and
present a therapeutic imperative for which we need additional insight into molecular …

Background: The genetic basis of amyloid β (Aβ) deposition in subcortical vascular cognitive
impairment (SVCI) is still unknown. Here, we investigated genetic variants involved in Aβ …

Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease. To identify
genes influencing Alzheimer's disease pathogenesis, we performed a genome-wide …

Importance While numerous genetic susceptibility loci have been identified for clinical
Alzheimer disease (AD), it is important to establish whether these variants are risk factors for …

Abstract Introduction Large variability among Alzheimer's disease (AD) cases might impact
genetic discoveries and complicate dissection of underlying biological pathways. Methods …

Objectives Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral
haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is …

Cerebral amyloid angiopathy (CAA) often coexists with Alzheimer's disease (AD). APOE4 is
a strong genetic risk factor for both AD and CAA. Sex-dependent differences have been …