Esophageal squamous cell carcinoma (ESCC), is the most common type of esophageal
cancer worldwide, mainly occurring in the Asian esophageal cancer belt, including northern …

Esophageal squamous cell carcinoma (ESCC) is a malignant tumor developing from the
esophageal squamous epithelium, and is the most common histological subtype of …

The abnormal phosphatase and tensin homolog expression and activated phosphoinositide-
3 kinase/Protein kinase B (AKT)/mammalian target of rapamycin signaling pathway are …

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

In the last decade, pathway-specific targeted therapy has revolutionized colorectal cancer
(CRC) treatment strategies. This type of therapy targets a tumor-vulnerable spot formed …

Background The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian
target of rapamycin (mTOR) pathway is implicated in several cancers. AKT allosteric inhibitor …

Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal, however,
the underlying mechanisms of CRC remain largely unknown. New evidence suggests that …

ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …

Esophageal cancer is the sixth most common cause of cancer-related deaths worldwide.
Novel therapeutic intervention is urgently needed for this deadly disease. The functional role …

Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …