Engineering a second‐order DNA logic‐gated nanorobot to sense and release on live cell membranes for multiplexed diagnosis and synergistic therapy
Tumor biomarker‐based theranostics have achieved broad interest and success in recent
years. However, single biomarker‐based recognition can cause false‐positive feedback …
years. However, single biomarker‐based recognition can cause false‐positive feedback …
A chimeric conjugate of antibody and programmable DNA nanoassembly smartly activates T cells for precise cancer cell targeting
R Tang, YH Fu, B Gong, YY Fan… - Angewandte Chemie …, 2022 - Wiley Online Library
Synthetically directing T‐cells against tumors emerges as a promising strategy in
immunotherapy, while it remains challenging to smartly engage T cells with tunable immune …
immunotherapy, while it remains challenging to smartly engage T cells with tunable immune …
Tunable multivalent aptamer-based DNA nanostructures to regulate multiheteroreceptor-mediated tumor recognition
X Hu, H Chi, X Fu, J Chen, L Dong… - Journal of the …, 2024 - ACS Publications
Precise mapping and regulation of cell surface receptors hold immense significance in
disease treatment, such as cancer, infection, and neurodisorders, but also face enormous …
disease treatment, such as cancer, infection, and neurodisorders, but also face enormous …
Engineering a 3D DNA-logic gate nanomachine for bispecific recognition and computing on target cell surfaces
R Peng, X Zheng, Y Lyu, L Xu, X Zhang… - Journal of the …, 2018 - ACS Publications
Among the vast number of recognition molecules, DNA aptamers generated from cell-
SELEX exhibit unique properties for identifying cell membrane biomarkers, in particular …
SELEX exhibit unique properties for identifying cell membrane biomarkers, in particular …
Programmable and multiparameter DNA-based logic platform for cancer recognition and targeted therapy
The specific inventory of molecules on diseased cell surfaces (eg, cancer cells) provides
clinicians an opportunity for accurate diagnosis and intervention. With the discovery of …
clinicians an opportunity for accurate diagnosis and intervention. With the discovery of …
Extracellular milieu and membrane receptor dual-driven DNA nanorobot for accurate in vivo tumor imaging
K Yuan, HM Meng, Y Wu, J Chen, H Xu, L Qu… - CCS …, 2022 - chinesechemsoc.org
Precise diagnostic approaches have great potential in cancer intervention and prognosis.
Although diverse DNA nanoprobes have been reported for tumor diagnosis, precise tumor …
Although diverse DNA nanoprobes have been reported for tumor diagnosis, precise tumor …
Construction of a multiple-aptamer-based DNA logic device on live cell membranes via associative toehold activation for accurate cancer cell identification
The ability to accurately identify and isolate cells is the cornerstone of precise disease
diagnosis and therapies. A single-step cell identification method based on logic analysis of …
diagnosis and therapies. A single-step cell identification method based on logic analysis of …
A Multivariate‐Gated DNA Nanodevice for Spatioselective Imaging of Pro‐metastatic Targets in Extracellular Microenvironment
Probing pro‐metastatic biomarkers is of significant importance to evaluate the risk of tumor
metastasis, but spatially selective imaging of such targets in extracellular microenvironment …
metastasis, but spatially selective imaging of such targets in extracellular microenvironment …
DNA “nano-claw”: logic-based autonomous cancer targeting and therapy
M You, L Peng, N Shao, L Zhang, L Qiu… - Journal of the …, 2014 - ACS Publications
Cell types, both healthy and diseased, can be classified by inventories of their cell-surface
markers. Programmable analysis of multiple markers would enable clinicians to develop a …
markers. Programmable analysis of multiple markers would enable clinicians to develop a …
A logic-gated nanorobot for targeted transport of molecular payloads
SM Douglas, I Bachelet, GM Church - Science, 2012 - science.org
We describe an autonomous DNA nanorobot capable of transporting molecular payloads to
cells, sensing cell surface inputs for conditional, triggered activation, and reconfiguring its …
cells, sensing cell surface inputs for conditional, triggered activation, and reconfiguring its …
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