Engineering a second‐order DNA logic‐gated nanorobot to sense and release on live cell membranes for multiplexed diagnosis and synergistic therapy

D Wang, S Li, Z Zhao, X Zhang… - Angewandte Chemie …, 2021 - Wiley Online Library
Tumor biomarker‐based theranostics have achieved broad interest and success in recent
years. However, single biomarker‐based recognition can cause false‐positive feedback …

A chimeric conjugate of antibody and programmable DNA nanoassembly smartly activates T cells for precise cancer cell targeting

R Tang, YH Fu, B Gong, YY Fan… - Angewandte Chemie …, 2022 - Wiley Online Library
Synthetically directing T‐cells against tumors emerges as a promising strategy in
immunotherapy, while it remains challenging to smartly engage T cells with tunable immune …

Tunable multivalent aptamer-based DNA nanostructures to regulate multiheteroreceptor-mediated tumor recognition

X Hu, H Chi, X Fu, J Chen, L Dong… - Journal of the …, 2024 - ACS Publications
Precise mapping and regulation of cell surface receptors hold immense significance in
disease treatment, such as cancer, infection, and neurodisorders, but also face enormous …

Engineering a 3D DNA-logic gate nanomachine for bispecific recognition and computing on target cell surfaces

R Peng, X Zheng, Y Lyu, L Xu, X Zhang… - Journal of the …, 2018 - ACS Publications
Among the vast number of recognition molecules, DNA aptamers generated from cell-
SELEX exhibit unique properties for identifying cell membrane biomarkers, in particular …

Programmable and multiparameter DNA-based logic platform for cancer recognition and targeted therapy

M You, G Zhu, T Chen, MJ Donovan… - Journal of the American …, 2015 - ACS Publications
The specific inventory of molecules on diseased cell surfaces (eg, cancer cells) provides
clinicians an opportunity for accurate diagnosis and intervention. With the discovery of …

Extracellular milieu and membrane receptor dual-driven DNA nanorobot for accurate in vivo tumor imaging

K Yuan, HM Meng, Y Wu, J Chen, H Xu, L Qu… - CCS …, 2022 - chinesechemsoc.org
Precise diagnostic approaches have great potential in cancer intervention and prognosis.
Although diverse DNA nanoprobes have been reported for tumor diagnosis, precise tumor …

Construction of a multiple-aptamer-based DNA logic device on live cell membranes via associative toehold activation for accurate cancer cell identification

X Chang, C Zhang, C Lv, Y Sun, M Zhang… - Journal of the …, 2019 - ACS Publications
The ability to accurately identify and isolate cells is the cornerstone of precise disease
diagnosis and therapies. A single-step cell identification method based on logic analysis of …

A Multivariate‐Gated DNA Nanodevice for Spatioselective Imaging of Pro‐metastatic Targets in Extracellular Microenvironment

Z Xiang, J Zhao, J Qu, J Song, L Li - Angewandte Chemie, 2022 - Wiley Online Library
Probing pro‐metastatic biomarkers is of significant importance to evaluate the risk of tumor
metastasis, but spatially selective imaging of such targets in extracellular microenvironment …

DNA “nano-claw”: logic-based autonomous cancer targeting and therapy

M You, L Peng, N Shao, L Zhang, L Qiu… - Journal of the …, 2014 - ACS Publications
Cell types, both healthy and diseased, can be classified by inventories of their cell-surface
markers. Programmable analysis of multiple markers would enable clinicians to develop a …

A logic-gated nanorobot for targeted transport of molecular payloads

SM Douglas, I Bachelet, GM Church - Science, 2012 - science.org
We describe an autonomous DNA nanorobot capable of transporting molecular payloads to
cells, sensing cell surface inputs for conditional, triggered activation, and reconfiguring its …