Altered microRNA regulation in Huntington's disease models
Huntington's disease (HD) is a genetic neurodegenerative disease caused by abnormal
CAG expansion. MicroRNAs (miRNAs) are short RNA molecules regulating gene …
CAG expansion. MicroRNAs (miRNAs) are short RNA molecules regulating gene …
[HTML][HTML] miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement
Background MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of
complementarity of target messenger RNAs, resulting in transcriptional regulation and …
complementarity of target messenger RNAs, resulting in transcriptional regulation and …
Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin
J Jin, Y Cheng, Y Zhang, W Wood… - Journal of …, 2012 - Wiley Online Library
Emerging evidence indicates that microRNAs (miRNAs) may play an important role in the
pathogenesis of Huntington's disease (HD). To identify the individual miRNAs that are …
pathogenesis of Huntington's disease (HD). To identify the individual miRNAs that are …
[HTML][HTML] microRNA-128a dysregulation in transgenic Huntington's disease monkeys
Abstract Background Huntington's Disease (HD) is a progressive neurodegenerative
disorder with a single causal mutation in the Huntingtin (HTT) gene. MicroRNAs (miRNAs) …
disorder with a single causal mutation in the Huntingtin (HTT) gene. MicroRNAs (miRNAs) …
[HTML][HTML] MicroRNAs in Huntington's disease: diagnostic biomarkers or therapeutic agents?
X Dong, S Cong - Frontiers in cellular neuroscience, 2021 - frontiersin.org
MicroRNA (miRNA) is a non-coding single-stranded small molecule of approximately 21
nucleotides. It degrades or inhibits the translation of RNA by targeting the 3′-UTR. The …
nucleotides. It degrades or inhibits the translation of RNA by targeting the 3′-UTR. The …
[HTML][HTML] miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models
PH Cheng, CL Li, YF Chang, SJ Tsai, YY Lai… - The American Journal of …, 2013 - cell.com
Huntington disease (HD) is a dominantly inherited neurodegenerative disorder
characterized by dysregulation of various genes. Recently, microRNAs (miRNAs) have been …
characterized by dysregulation of various genes. Recently, microRNAs (miRNAs) have been …
[HTML][HTML] Supplemental treatment for Huntington's disease with miR-132 that is deficient in Huntington's disease brain
M Fukuoka, M Takahashi, H Fujita, T Chiyo… - … Therapy-Nucleic Acids, 2018 - cell.com
Huntington's disease (HD) is an intractable neurodegenerative disorder caused by mutant
Huntingtin (HTT) proteins that adversely affect various biomolecules and genes. MicroRNAs …
Huntingtin (HTT) proteins that adversely affect various biomolecules and genes. MicroRNAs …
Micro RNA -214,-150,-146a and-125b target Huntingtin gene
We observed earlier that expressions of several micro RNAs (miRNAs) are altered in a cell
model of Huntington's disease (HD). As genes involved in different neurodegenerative …
model of Huntington's disease (HD). As genes involved in different neurodegenerative …
[HTML][HTML] MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis
Transcriptional dysregulation has long been recognized as central to the pathogenesis of
Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post …
Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post …
Circulating microRNAs in Huntington's disease: Emerging mediators in metabolic impairment
C Díez-Planelles, P Sánchez-Lozano… - Pharmacological …, 2016 - Elsevier
Huntington's disease (HD) is a hereditary neurodegenerative disease, with peripheral
consequences that negatively contribute to quality of life. Circulating microRNAs (cmiRNAs) …
consequences that negatively contribute to quality of life. Circulating microRNAs (cmiRNAs) …