Altered microRNA regulation in Huntington's disease models

ST Lee, K Chu, WS Im, HJ Yoon, JY Im, JE Park… - Experimental …, 2011 - Elsevier
Huntington's disease (HD) is a genetic neurodegenerative disease caused by abnormal
CAG expansion. MicroRNAs (miRNAs) are short RNA molecules regulating gene …

[HTML][HTML] miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement

AG Hoss, A Labadorf, JC Latourelle, VK Kartha… - BMC medical …, 2015 - Springer
Background MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of
complementarity of target messenger RNAs, resulting in transcriptional regulation and …

Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin

J Jin, Y Cheng, Y Zhang, W Wood… - Journal of …, 2012 - Wiley Online Library
Emerging evidence indicates that microRNAs (miRNAs) may play an important role in the
pathogenesis of Huntington's disease (HD). To identify the individual miRNAs that are …

[HTML][HTML] microRNA-128a dysregulation in transgenic Huntington's disease monkeys

J Kocerha, Y Xu, MS Prucha, D Zhao, AWS Chan - Molecular brain, 2014 - Springer
Abstract Background Huntington's Disease (HD) is a progressive neurodegenerative
disorder with a single causal mutation in the Huntingtin (HTT) gene. MicroRNAs (miRNAs) …

[HTML][HTML] MicroRNAs in Huntington's disease: diagnostic biomarkers or therapeutic agents?

X Dong, S Cong - Frontiers in cellular neuroscience, 2021 - frontiersin.org
MicroRNA (miRNA) is a non-coding single-stranded small molecule of approximately 21
nucleotides. It degrades or inhibits the translation of RNA by targeting the 3′-UTR. The …

[HTML][HTML] miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models

PH Cheng, CL Li, YF Chang, SJ Tsai, YY Lai… - The American Journal of …, 2013 - cell.com
Huntington disease (HD) is a dominantly inherited neurodegenerative disorder
characterized by dysregulation of various genes. Recently, microRNAs (miRNAs) have been …

[HTML][HTML] Supplemental treatment for Huntington's disease with miR-132 that is deficient in Huntington's disease brain

M Fukuoka, M Takahashi, H Fujita, T Chiyo… - … Therapy-Nucleic Acids, 2018 - cell.com
Huntington's disease (HD) is an intractable neurodegenerative disorder caused by mutant
Huntingtin (HTT) proteins that adversely affect various biomolecules and genes. MicroRNAs …

Micro RNA -214,-150,-146a and-125b target Huntingtin gene

M Sinha, J Ghose, NP Bhattarcharyya - RNA biology, 2011 - Taylor & Francis
We observed earlier that expressions of several micro RNAs (miRNAs) are altered in a cell
model of Huntington's disease (HD). As genes involved in different neurodegenerative …

[HTML][HTML] MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis

AG Hoss, VK Kartha, X Dong, JC Latourelle… - PLoS …, 2014 - journals.plos.org
Transcriptional dysregulation has long been recognized as central to the pathogenesis of
Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post …

Circulating microRNAs in Huntington's disease: Emerging mediators in metabolic impairment

C Díez-Planelles, P Sánchez-Lozano… - Pharmacological …, 2016 - Elsevier
Huntington's disease (HD) is a hereditary neurodegenerative disease, with peripheral
consequences that negatively contribute to quality of life. Circulating microRNAs (cmiRNAs) …