Introduction The intrinsic autofluorescence of biological tissues interferes with the detection
of fluorophores administered for fluorescence guidance, an emerging auxiliary technique in …

OBJECTIVE: Intraoperative detection of residual tumor tissue in glioma surgery remains an
important challenge because the extent of tumor removal is related to the prognosis of the …

The primary therapeutic approach for high-grade brain tumor is surgical resection. However,
identifying tumor margins in vivo remains a major challenge. Biopsy analysis remains the …

Malignant gliomas, among others the glioblastoma multiforme, are the most frequent brain
tumors. The glioblastoma itself represents the most unfavorable tumor. In Switzerland, about …

Fluorescence spectroscopy of endogenous emission of brain tumors, in particular
glioblastoma multiforme, will be used for intraoperative localization of brain tumor margins …

Fluorescence spectroscopy of the endogenous emission of brain tumors has been
researched as a potentially important method for the intraoperative localization of brain …

One of the main neurosurgical problem consists in accurately identify the margins of brain
tumors to allow a tumor's precise excision without destruction of the surrounding healthy …

Background Only sporadic reports of fluorescence-guided surgery (FGS) have been
published for non-glioma conditions. In this study, we focus on epidemiological data of …

OBJECTIVE Raman spectroscopy is a biophotonic tool that can be used to differentiate
between different tissue types. It is nondestructive and no sample preparation is required …

Multiphoton excitation fluorescent microscopy is a laser-based technology that allows
subcellular resolution of native tissues in situ. We have recently applied this technology to …