Rationale: The relative roles of mucus plugs and emphysema in mechanisms of airflow
limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) …

Importance Airway mucus plugs are common in patients with chronic obstructive pulmonary
disease (COPD); however, the association of airway mucus plugging and mortality in …

Rationale: Cross-sectional analysis of mucus plugs in computed tomography (CT) lung
scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug …

Background Mucous exudates occluding the lumen of small airways are associated with
reduced lung function and mortality in subjects with COPD; however, luminal plugs in large …

Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow
obstruction caused by emphysema or airway narrowing, or both. Low attenuation areas …

Rationale: Emphysema occurs in distinct pathologic patterns, but little is known about the
epidemiologic associations of these patterns. Standard quantitative measures of …

Rationale: Chronic mucus hypersecretion (CMH) is common among smokers and is
associated with chronic obstructive pulmonary disease development and progression …

Background The severities of COPD (FEV 1% predicted) and airflow obstruction (FEV
1/FVC) are considered to be due to both emphysema and small airways disease. To our …

Most patients with chronic obstructive pulmonary disease (COPD) exhibit characteristics of
airway mucus hypersecretion, namely sputum production, increased luminal mucus …

Background CT is used to quantify abnormal changes in the lung parenchyma of smokers
that might overlap chronic obstructive pulmonary disease (COPD), but studies on the …