The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments

P Solár, A Zamani, K Lakatosová, M Joukal - Fluids and Barriers of the …, 2022 - Springer
The response of the blood–brain barrier (BBB) following a stroke, including subarachnoid
hemorrhage (SAH), has been studied extensively. The main components of this reaction are …

Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage

H Kanamaru, H Suzuki - Neural regeneration research, 2019 - journals.lww.com
Aneurysmal subarachnoid hemorrhage remains serious hemorrhagic stroke with high
morbidities and mortalities. Aneurysm rupture causes arterial bleeding-induced mechanical …

The updated role of the blood brain barrier in subarachnoid hemorrhage: from basic and clinical studies

S Chen, PL Xu, YJ Fang… - Current …, 2020 - ingentaconnect.com
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke associated with high
mortality and morbidity. The blood-brain-barrier (BBB) is a structure consisting primarily of …

Underlying mechanisms and potential therapeutic molecular targets in blood-brain barrier disruption after subarachnoid hemorrhage

Y Li, P Wu, JC Bihl, H Shi - Current neuropharmacology, 2020 - ingentaconnect.com
Aneurysmal subarachnoid hemorrhage (aSAH) is a subtype of hemorrhagic stroke with
significant morbidity and mortality. Aneurysmal bleeding causes elevated intracranial …

Endothelial cell dysfunction and injury in subarachnoid hemorrhage

T Peeyush Kumar, DW McBride, PK Dash… - Molecular …, 2019 - Springer
In the brain, vascular endothelial cells conserve blood viscosity, control blood flow, and form
the interface between central nervous system and circulating blood. Clinical outcome after …

Subarachnoid hemorrhage: a review of experimental studies on the microcirculation and the neurovascular unit

MK Tso, RL Macdonald - Translational stroke research, 2014 - Springer
Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated
early brain injury and the microcirculation. A number of pathophysiological changes occur in …

Neurovascular events after subarachnoid hemorrhage: focusing on subcellular organelles

S Chen, H Wu, J Tang, J Zhang, JH Zhang - Neurovascular Events After …, 2015 - Springer
Subarachnoid hemorrhage (SAH) is a devastating condition with high morbidity and
mortality rates due to the lack of effective therapy. Early brain injury (EBI) and cerebral …

Molecular mechanisms of early brain injury after subarachnoid hemorrhage

RP Ostrowski, AR Colohan, JH Zhang - Neurological research, 2006 - Taylor & Francis
Objectives: Increasing body of experimental and clinical data indicates that early brain injury
after initial bleeding largely contributes to unfavorable outcome after subarachnoid …

The contractile apparatus is essential for the integrity of the blood-brain barrier after experimental subarachnoid hemorrhage

C Luh, S Feiler, K Frauenknecht, S Meyer… - Translational stroke …, 2019 - Springer
Abstract Development of vasogenic brain edema is a key event contributing to mortality after
subarachnoid hemorrhage (SAH). The precise underlying mechanisms at the neurovascular …

Inflammation: a good research target to improve outcomes of poor-grade subarachnoid hemorrhage

H Suzuki - Translational Stroke Research, 2019 - Springer
Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating cerebrovascular
disease [1] and should be treated as a systemic disorder needing intensive care, not merely …