Epigenetic signatures of cigarette smoking

R Joehanes, AC Just, RE Marioni… - Circulation …, 2016 - Am Heart Assoc
Background—DNA methylation leaves a long-term signature of smoking exposure and is
one potential mechanism by which tobacco exposure predisposes to adverse health …

Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility

PA Dugué, CH Jung, JE Joo, X Wang, EM Wong… - Epigenetics, 2020 - Taylor & Francis
We conducted a genome-wide association study of blood DNA methylation and smoking,
attempted replication of previously discovered associations, and assessed the reversibility of …

Epigenetic signatures of starting and stopping smoking

DL McCartney, AJ Stevenson, RF Hillary, RM Walker… - …, 2018 - thelancet.com
Background Multiple studies have made robust associations between differential DNA
methylation and exposure to cigarette smoke. But whether a DNA methylation phenotype is …

Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

J van Dongen, G Willemsen, EJC de Geus… - Elife, 2023 - elifesciences.org
Background: Smoking-associated DNA methylation levels identified through epigenome-
wide association studies (EWASs) are generally ascribed to smoking-reactive mechanisms …

The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers

R Wilson, S Wahl, L Pfeiffer, CK Ward-Caviness… - BMC genomics, 2017 - Springer
Background The evidence for epigenome-wide associations between smoking and DNA
methylation continues to grow through cross-sectional studies. However, few large-scale …

Tobacco smoking leads to extensive genome-wide changes in DNA methylation

S Zeilinger, B Kühnel, N Klopp, H Baurecht… - PloS one, 2013 - journals.plos.org
Environmental factors such as tobacco smoking may have long-lasting effects on DNA
methylation patterns, which might lead to changes in gene expression and in a broader …

Self-reported smoking, serum cotinine, and blood DNA methylation

Y Zhang, I Florath, KU Saum, H Brenner - Environmental research, 2016 - Elsevier
Background Epigenome-wide profiling of DNA methylation pattern with respect to tobacco
smoking has given rise to a new measure of smoking exposure. We investigated the …

DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

X Gao, M Jia, Y Zhang, LP Breitling, H Brenner - Clinical epigenetics, 2015 - Springer
Active smoking is a major preventable public health problem and an established critical
factor for epigenetic modification. In this systematic review, we identified 17 studies …

Cigarette smoking and DNA methylation

KWK Lee, Z Pausova - Frontiers in genetics, 2013 - frontiersin.org
DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …

Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans

YV Sun, AK Smith, KN Conneely, Q Chang, W Li… - Human genetics, 2013 - Springer
Cigarette smoking is an environmental risk factor for many chronic diseases, and disease
risk can often be managed by smoking control. Smoking can induce cellular and molecular …