Rebuilding brain circuitry with living micro-tissue engineered neural networks

LA Struzyna, JA Wolf, CJ Mietus… - … Engineering Part A, 2015 - liebertpub.com
Prominent neuropathology following trauma, stroke, and various neurodegenerative
diseases includes neuronal degeneration as well as loss of long-distance axonal …

Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain

JP Harris, LA Struzyna, PL Murphy… - Journal of neural …, 2016 - iopscience.iop.org
Objective. Connectome disruption is a hallmark of many neurological diseases and trauma
with no current strategies to restore lost long-distance axonal pathways in the brain. We are …

Anatomically inspired three-dimensional micro-tissue engineered neural networks for nervous system reconstruction, modulation, and modeling

LA Struzyna, DO Adewole, WJ Gordián-Vélez… - JoVE (Journal of …, 2017 - jove.com
Functional recovery rarely occurs following injury or disease-induced degeneration within
the central nervous system (CNS) due to the inhibitory environment and the limited capacity …

Microtissue engineered constructs with living axons for targeted nervous system reconstruction

DK Cullen, MD Tang-Schomer, LA Struzyna… - … Engineering Part A, 2012 - liebertpub.com
As a common feature of many neurological diseases and injury, the loss of axon pathways
can have devastating effects on function. Here, we demonstrate a new strategy to restore …

Restoring nervous system structure and function using tissue engineered living scaffolds

LA Struzyna, JP Harris, KS Katiyar… - Neural regeneration …, 2015 - journals.lww.com
Neural tissue engineering is premised on the integration of engineered living tissue with the
host nervous system to directly restore lost function or to augment regenerative capacity …

Neural tissue engineering for neuroregeneration and biohybridized interface microsystems in vivo (Part 2)

DK Cullen, JA Wolf, DH Smith… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Neural tissue engineering offers tremendous promise to combat the effects of disease,
aging, or injury in the nervous system. Here we review neural tissue engineering with …

Interfacing cells with microengineered scaffolds for neural tissue reconstruction

A Accardo, C Cirillo, S Lionnet, C Vieu… - Brain Research Bulletin, 2019 - Elsevier
The development of cellular microenvironments suitable for neural tissue engineering
purposes involves a plethora of research fields ranging from cell biology to biochemistry …

In vivo neural tissue engineering: cylindrical biocompatible hydrogels that create new neural tracts in the adult mammalian brain

AR Clark, AB Carter, LE Hager… - Stem cells and …, 2016 - liebertpub.com
Individuals with neurodegenerative disorders or brain injury have few treatment options and
it has been proposed that endogenous adult neural stem cells can be harnessed to …

Neural tissue engineering: From bioactive scaffolds and in situ monitoring to regeneration

B Gong, X Zhang, AA Zahrani, W Gao, G Ma… - …, 2022 - Wiley Online Library
Peripheral nerve injury is a large‐scale problem that annually affects more than several
millions of people all over the world. It remains a great challenge to effectively repair nerve …

Assessing functional connectivity across 3D tissue engineered axonal tracts using calcium fluorescence imaging

AV Dhobale, DO Adewole, AHW Chan… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Micro-tissue engineered neural networks (micro-TENNs) are anatomically-
inspired constructs designed to structurally and functionally emulate white matter pathways …