Rebuilding brain circuitry with living micro-tissue engineered neural networks
LA Struzyna, JA Wolf, CJ Mietus… - … Engineering Part A, 2015 - liebertpub.com
Prominent neuropathology following trauma, stroke, and various neurodegenerative
diseases includes neuronal degeneration as well as loss of long-distance axonal …
diseases includes neuronal degeneration as well as loss of long-distance axonal …
Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain
JP Harris, LA Struzyna, PL Murphy… - Journal of neural …, 2016 - iopscience.iop.org
Objective. Connectome disruption is a hallmark of many neurological diseases and trauma
with no current strategies to restore lost long-distance axonal pathways in the brain. We are …
with no current strategies to restore lost long-distance axonal pathways in the brain. We are …
Anatomically inspired three-dimensional micro-tissue engineered neural networks for nervous system reconstruction, modulation, and modeling
LA Struzyna, DO Adewole, WJ Gordián-Vélez… - JoVE (Journal of …, 2017 - jove.com
Functional recovery rarely occurs following injury or disease-induced degeneration within
the central nervous system (CNS) due to the inhibitory environment and the limited capacity …
the central nervous system (CNS) due to the inhibitory environment and the limited capacity …
Microtissue engineered constructs with living axons for targeted nervous system reconstruction
DK Cullen, MD Tang-Schomer, LA Struzyna… - … Engineering Part A, 2012 - liebertpub.com
As a common feature of many neurological diseases and injury, the loss of axon pathways
can have devastating effects on function. Here, we demonstrate a new strategy to restore …
can have devastating effects on function. Here, we demonstrate a new strategy to restore …
Restoring nervous system structure and function using tissue engineered living scaffolds
LA Struzyna, JP Harris, KS Katiyar… - Neural regeneration …, 2015 - journals.lww.com
Neural tissue engineering is premised on the integration of engineered living tissue with the
host nervous system to directly restore lost function or to augment regenerative capacity …
host nervous system to directly restore lost function or to augment regenerative capacity …
Neural tissue engineering for neuroregeneration and biohybridized interface microsystems in vivo (Part 2)
Neural tissue engineering offers tremendous promise to combat the effects of disease,
aging, or injury in the nervous system. Here we review neural tissue engineering with …
aging, or injury in the nervous system. Here we review neural tissue engineering with …
Interfacing cells with microengineered scaffolds for neural tissue reconstruction
The development of cellular microenvironments suitable for neural tissue engineering
purposes involves a plethora of research fields ranging from cell biology to biochemistry …
purposes involves a plethora of research fields ranging from cell biology to biochemistry …
In vivo neural tissue engineering: cylindrical biocompatible hydrogels that create new neural tracts in the adult mammalian brain
AR Clark, AB Carter, LE Hager… - Stem cells and …, 2016 - liebertpub.com
Individuals with neurodegenerative disorders or brain injury have few treatment options and
it has been proposed that endogenous adult neural stem cells can be harnessed to …
it has been proposed that endogenous adult neural stem cells can be harnessed to …
Neural tissue engineering: From bioactive scaffolds and in situ monitoring to regeneration
B Gong, X Zhang, AA Zahrani, W Gao, G Ma… - …, 2022 - Wiley Online Library
Peripheral nerve injury is a large‐scale problem that annually affects more than several
millions of people all over the world. It remains a great challenge to effectively repair nerve …
millions of people all over the world. It remains a great challenge to effectively repair nerve …
Assessing functional connectivity across 3D tissue engineered axonal tracts using calcium fluorescence imaging
AV Dhobale, DO Adewole, AHW Chan… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Micro-tissue engineered neural networks (micro-TENNs) are anatomically-
inspired constructs designed to structurally and functionally emulate white matter pathways …
inspired constructs designed to structurally and functionally emulate white matter pathways …