Anticancer chemotherapy drugs challenge hematopoietic tissues to regenerate but
commonly produce long-term sequelae. Chemotherapy-induced deficits in hematopoietic …

The sympathetic nervous system has been evolutionary selected to respond to stress and
activates haematopoietic stem cells via noradrenergic signals. However, the pathways …

Haematopoietic stem cells (HSCs) reside in specialized microenvironments in the bone
marrow—often referred to as 'niches'—that represent complex regulatory milieux influenced …

Exposure to psychosocial stress is a risk factor for many diseases, including
atherosclerosis,. Although incompletely understood, interaction between the psyche and the …

Chemotherapy-induced peripheral neuropathy is one of the most prevalent dose-limiting
toxicities of anticancer therapy. Development of effective therapies to prevent chemotherapy …

Perivascular mesenchymal stem and progenitor cells (MSPCs) are critical for forming a
healthy hematopoietic stem cell (HSC) niche. However, the interactions and influence of …

Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the
haematopoietic stem cell (HSC) compartment. Most MPN patients have a common acquired …

Myeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth
and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor …

Chemotherapeutic agents cause many short and long term toxic side effects to peripheral
nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral …

The mechanisms responsible for the persistence of chemotherapy-induced peripheral
neuropathy (CIPN) in a significant proportion of cancer survivors are still unknown. Our …