[HTML][HTML] Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion
Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been
administered to humans. However, we lack a comprehensive understanding of the immune …
administered to humans. However, we lack a comprehensive understanding of the immune …
[HTML][HTML] A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high
transmissibility of the virus and the high rate of morbidity and mortality associated with …
transmissibility of the virus and the high rate of morbidity and mortality associated with …
[HTML][HTML] Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2
Lipid nanoparticle (LNP)-mRNA vaccines offer protection against COVID-19; however,
multiple variant lineages caused widespread breakthrough infections. Here, we generate …
multiple variant lineages caused widespread breakthrough infections. Here, we generate …
[HTML][HTML] Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species
Although COVID-19 vaccines have been developed, multiple pathogenic coronavirus
species exist, urging on development of multispecies coronavirus vaccines. Here we …
species exist, urging on development of multispecies coronavirus vaccines. Here we …
Innate immune mechanisms of mRNA vaccines
The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
[HTML][HTML] Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 immune responses
Nucleoside modified mRNA combined with Acuitas Therapeutics' lipid nanoparticles (LNPs)
has been shown to support robust humoral immune responses in many preclinical animal …
has been shown to support robust humoral immune responses in many preclinical animal …
[HTML][HTML] Durable cross-protective neutralizing antibody responses elicited by lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccines
The advent of SARS-CoV-2 variants with defined mutations that augment pathogenicity
and/or increase immune evasiveness continues to stimulate global efforts to improve …
and/or increase immune evasiveness continues to stimulate global efforts to improve …
[HTML][HTML] Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
Lipid nanoparticle (LNP)-formulated messenger RNA (mRNA) vaccineare a promising
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
[HTML][HTML] An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants
R Uraki, M Imai, M Ito, S Yamayoshi, M Kiso, N Jounai… - npj Vaccines, 2024 - nature.com
Here, we assessed the efficacy of a lipid nanoparticle-based mRNA vaccine candidate
encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with …
encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with …
[HTML][HTML] Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2
The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …