Precision oncology in metastatic colorectal cancer—from biology to medicine

F Di Nicolantonio, PP Vitiello, S Marsoni… - Nature reviews Clinical …, 2021 - nature.com
Remarkable progress has been made in the development of biomarker-driven targeted
therapies for patients with multiple cancer types, including melanoma, breast and lung …

The evolving biomarker landscape for treatment selection in metastatic colorectal cancer

J Taieb, A Jung, A Sartore-Bianchi, M Peeters… - Drugs, 2019 - Springer
The approval of targeted therapies for metastatic colorectal cancer (mCRC) has led to
important improvements in patient outcomes. However, it is still necessary to increase …

Precision medicine for metastatic colorectal cancer: an evolving era

I Guler, G Askan, J Klostergaard… - Expert review of …, 2019 - Taylor & Francis
Introduction: Metastatic colorectal cancer (CRC) remains a dilemma for cancer researchers
with an increasing incidence in the younger patient population. Until the last decade, limited …

Recent developments in the treatment of metastatic colorectal cancer

JM Loree, S Kopetz - Therapeutic advances in medical …, 2017 - journals.sagepub.com
Over the past decade there have been significant advances in the molecular
characterization of colorectal cancer (CRC) that are driving treatment decisions. Expanded …

[HTML][HTML] Targeted therapy in metastatic colorectal cancer–an example of personalised medicine in action

V Heinemann, JY Douillard, M Ducreux… - Cancer treatment …, 2013 - Elsevier
In metastatic colorectal cancer (mCRC), an improved understanding of the underlying
pathology and molecular biology has successfully merged with advances in diagnostic …

Molecular markers in the treatment of metastatic colorectal cancer

PM Wilson, MJ LaBonte, HJ Lenz - The Cancer Journal, 2010 - journals.lww.com
Although significant progress has been made in colorectal cancer (CRC) treatment within
the last decade with the approval of multiple new agents, the prognosis for patients with …

Targeting EGFR pathway in metastatic colorectal cancer-tumour heterogeniety and convergent evolution

K Khan, N Valeri, C Dearman, S Rao, D Watkins… - Critical reviews in …, 2019 - Elsevier
Despite significant progress in management of metastatic colorectal cancer (mCRC)
pertaining to better screening procedures and amelioration of the therapeutic …

Clinical management of metastatic colorectal cancer in the era of precision medicine

F Ciardiello, D Ciardiello, G Martini… - CA: a cancer journal …, 2022 - Wiley Online Library
Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …

Metastatic colorectal cancer in the era of personalized medicine: a more tailored approach to systemic therapy

IS Yu, WY Cheung - Canadian Journal of Gastroenterology and …, 2018 - Wiley Online Library
Colorectal cancer is the second most common malignancy diagnosed in Canada. Despite
declining incidence and mortality rates in recent years, there is still a significant number of …

Molecular targets for the treatment of metastatic colorectal cancer

R Cohen, T Pudlarz, JF Delattre, R Colle, T André - Cancers, 2020 - mdpi.com
Over the past years, colorectal cancer (CRC) was subtyped according to its molecular and
genetic characteristics, allowing the development of therapeutic strategies, based on …