Localized radiotherapy (RT) induces an immunogenic antitumor response that is in part
counterbalanced by activation of immune evasive and tissue remodeling processes, eg, via …

Purpose: Radiotherapy is a highly effective anticancer treatment forming part of the standard
of care for the majority of patients, but local and distal disease recurrence remains a major …

Fractionated radiation therapy (RT) leads to adaptive changes in the tumor
microenvironment that may limit the generation of an antitumor immune response. We …

T cells directed to endogenous tumor antigens are powerful mediators of tumor regression.
Recent immunotherapy advances have identified effective interventions to unleash tumor …

Background Despite some successes with checkpoint inhibitors for treating cancer, most
patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor …

Homing of CD8+ T lymphocytes to the tumor microenvironment is an important step for
mounting a robust antitumor immune response. TGFβ is responsible for CD103 (αEβ7) …

Interest in combining radiotherapy and immune checkpoint therapy is growing rapidly. In this
study, we explored a novel combination of this type to augment antitumor immune …

Purpose: Radiotherapy (RT) is frequently used for local control of solid tumors using equal
dose per fraction. Recently, single high-dose radiation has been used for ablation of solid …

Successful combinations of radiotherapy and immunotherapy depend on the presence of
live T cells within the tumor; however, radiotherapy is believed to damage T cells. Here …

Radiotherapy is a major part in the treatment of most common cancers, but many patients
experience local recurrence with metastatic disease. In evaluating response biomarkers, we …