Colorectal cancer (CRC) results from the accumulation of both genetic and epigenetic
alterations of the genome. However, also the formation of an inflammatory milieu plays a …

Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading
cause of cancer-related deaths worldwide. Locally advanced and metastatic disease exhibit …

The complexity of the tumor immunoenvironment is underscored by the emergence and
discovery of different subsets of immune effectors and regulatory cells. Tumor-induced …

Dendritic cells (DCs) either boost the immune system (enhancing immunity) or dampen it
(leading to tolerance). This dual effect explains their vital role in cancer development and …

Colorectal cancer (CRC), a multi-step malignancy showing increasing incidence in today's
societies, represents an important worldwide health issue. Exogenous factors, such as …

Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC
are recruited at the site of antigen expression, uptake antigens and migrate to secondary …

Several reports have demonstrated that tumours are not intrinsically resistant to the immune
response. However, neoplasias commonly fail to initiate and maintain adequate immunity. A …

Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths in Western
countries. Today, the role of the host's immune system in controlling the progression and …

Highlights•All major subsets of DCs are critical component of anti-tumor immunity.•DCs in
TME show defects in differentiation, activation and functions.•The presence inf-DCs with anti …

A common characteristic of solid tumors is the pathological recruitment of
immunosuppressive myeloid cells, which in certain tumors includes dendritic cells (DCs) …