1 FPL 63547, in its active diacid form, was a potent inhibitor of rabbit lung angiotensin
converting enzyme (ACE) in vitro (IC50 0.51 nm). 2 In conscious normotensive dogs, FPL …

1 The route of elimination of FPL 63547, a novel inhibitor of angiotensin‐converting enzyme
(ACE), has been investigated in the anaesthetized rat. Comparisons have been made with …

SCH 33844 is a new, potent and long-acting inhibitor of angiotensin converting enzyme
(ACE). Antihypertensive, hemodynamic and autonomic actions of SCH 33844 were …

1 We investigated the role of angiotensin converting enzyme (ACE) in the cardiovascular
effects of N‐[1‐(R, S)‐carboxy‐3‐phenylpropyl]‐Ala‐Ala‐Tyr‐p‐aminobenzoate (cFP), a …

SCH 33844 is a new non-sulfhydryl-containing angiotensin converting enzyme (ACE)
inhibitor. SCH 33844 diacid inhibited hydrolysis of the synthetic substrate hippuryl-histidyl …

1 The new converting enzyme inhibitor RHC 3659 was tested in 15 male volunteers. The
study consisted of two parts: first, the ability of a single oral dose (5, 10, 20, 40 or 80 mg) to …

The development of angiotensin converting enzyme inhibitors is often cited as a prime
example of task oriented research. The truth is far from this, and, as so often, chance played …

1. Seven drugs (captopril, zofenopril, enalapril, ramipril, lisinopril, fosinopril, and SQ 29,852)
were compared in vitro in homogenates of aorta, brain, heart, lung, and kidney and in sera of …

Recent clinical data demonstrate that angiotensin converting enzyme (ACE) inhibitors
possess promising antihypertensive properties. We now report on the ACE inhibitory activity …

1 In the anaesthetized open‐chest dog, BW A575C (N‐(1‐(S)‐carboxy‐5‐[4 (3‐
isopropylamino‐2‐(R, S)‐hydroxypropoxy) indole‐2‐carboxamido] pentyl)‐(R, S)‐alanyl‐(S) …