In an era when cancer glycobiology research is exponentially growing, we are witnessing a
progressive translation of the major scientific findings to the clinical practice with the …

Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an
intriguing subject of study for their complex structural characteristics, their finely regulated …

Cell-surface/extracellular-matrix heparan-sulphate glycosaminoglycans (HSGAGs) are
complex polysaccharides that are ubiquitous in nature, and that regulate several aspects of …

Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily
modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains …

The biology of tumor cells strictly depends on their microenvironment architecture and
composition, which controls the availability of growth factors and signaling molecules. Thus …

The heparan sulfate proteoglycans (HSPGs) are glycoproteins that consist of a proteoglycan
“core” protein and covalently attached heparan sulfate (HS) chain. HSPGs are ubiquitously …

Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and
progression, by interacting with the signaling pathways that affect proliferation, adhesion …

Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …

Heparan sulfate is a ubiquitous, variably sulfated interactive glycosaminoglycan that
consists of repeating disaccharides of glucuronic acid and glucosamine that are subject to a …