In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …

MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …

The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …

Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In
adult mammalian hearts, most cardiomyocytes are terminally differentiated and have …

We recently identified a brief time period during postnatal development when the
mammalian heart retains significant regenerative potential after amputation of the ventricular …

MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for
the treatment of myocardial infarction. In previous work, we showed that the miR-302/367 …

A growing body of evidence indicates that cardiac regeneration after myocardial infarction
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …

Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac
myocytes, which is characterized by an increase in cell size, enhanced protein synthesis …

Rationale: Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal
development, which significantly limits the capacity of the adult mammalian heart to …

Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …