Functional screening identifies miRNAs inducing cardiac regeneration
A Eulalio, M Mano, MD Ferro, L Zentilin, G Sinagra… - Nature, 2012 - nature.com
In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
KR Cordes, NT Sheehy, MP White, EC Berry… - Nature, 2009 - nature.com
MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …
MicroRNAs and cardiac regeneration
The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …
miRNA in cardiac development and regeneration
Z Ouyang, K Wei - Cell Regeneration, 2021 - Springer
Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In
adult mammalian hearts, most cardiomyocytes are terminally differentiated and have …
adult mammalian hearts, most cardiomyocytes are terminally differentiated and have …
Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family
ER Porrello, AI Mahmoud, E Simpson… - Proceedings of the …, 2013 - National Acad Sciences
We recently identified a brief time period during postnatal development when the
mammalian heart retains significant regenerative potential after amputation of the ventricular …
mammalian heart retains significant regenerative potential after amputation of the ventricular …
Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury
LL Wang, Y Liu, JJ Chung, T Wang, AC Gaffey… - Nature biomedical …, 2017 - nature.com
MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for
the treatment of myocardial infarction. In previous work, we showed that the miR-302/367 …
the treatment of myocardial infarction. In previous work, we showed that the miR-302/367 …
Non-coding RNA therapeutics for cardiac regeneration
A growing body of evidence indicates that cardiac regeneration after myocardial infarction
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
E Van Rooij, LB Sutherland, N Liu… - Proceedings of the …, 2006 - National Acad Sciences
Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac
myocytes, which is characterized by an increase in cell size, enhanced protein synthesis …
myocytes, which is characterized by an increase in cell size, enhanced protein synthesis …
MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes
ER Porrello, BA Johnson, AB Aurora… - Circulation …, 2011 - Am Heart Assoc
Rationale: Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal
development, which significantly limits the capacity of the adult mammalian heart to …
development, which significantly limits the capacity of the adult mammalian heart to …
MicroRNA-133 controls cardiac hypertrophy
Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …