To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and
conservation of large numbers of phosphorylation sites for the cyclin-dependent kinase …

The events of cell reproduction are governed by oscillations in the activities of cyclin-
dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of …

The quantitative model of cyclin-dependent kinase (CDK) function states that cyclins
temporally order cell cycle events at different CDK activity levels, or thresholds. The model …

The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher
eukaryotes. Dominant-negative mutations were used to address the requirement for kinases …

Cell division is thought to be initiated by cyclin-dependent kinases (Cdks) inactivating key
transcriptional inhibitors. In budding yeast, the G1 cyclin Cln3-Cdk1 complex is thought to …

In higher eukaryotes, the S phase and M phase of the cell cycle are triggered by different
cyclin-dependent kinases (CDKs). For example, in frog egg extracts, Cdk1–cyclin B …

The activation of cyclin-dependent kinases (CDKs) requires the phosphorylation of a
conserved threonine (Thr160 in Cdk2) by CDK-activating kinase (CAK). Human KAP (also …

Background Protein phosphorylation regulates a multitude of biological processes.
However, the large number of protein kinases and their substrates generates an enormously …

The order and timing of cell-cycle events is controlled by changing substrate specificity and
different activity thresholds of cyclin-dependent kinases (CDKs). However, it is not …

Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic
activation is driven by cyclins. Different cyclins promote distinct cell-cycle events, but the …