The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …

Eukaryotic genomes are organized into higher order chromatin architectures by protein-
mediated long-range interactions in the nucleus. CCCTC-binding factor (CTCF), a sequence …

Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …

It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only
marginally affects expression of most genes despite substantially perturbing three …

Recent studies indicate that even a homogeneous population of cells display heterogeneity
in gene expression and response to environmental stimuli. Although promoter structure …

Developmental gene expression is often controlled by distal regulatory DNA elements called
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …

The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function
together to shape chromatin architecture in mammalian cells, but the molecular details of …

Coordinated chromatin interactions between enhancers and promoters are critical for gene
regulation. The architectural protein CTCF mediates chromatin looping and is enriched at …

To understand how chromatin domains coordinate gene expression, we dissected select
genetic elements organizing topology and transcription around the Prdm14 super enhancer …

CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional
(3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of …