Research on the neurobiology of the kynurenine pathway has suffered years of relative
obscurity because tryptophan degradation, and its involvement in both physiology and major …

The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3 …

Psychiatric disorders are documented to be associated with a mild pro‐inflammatory state.
Pro‐inflammatory mediators could activate the tryptophan breakdown and kynurenine …

In just under 20 years the kynurenine family of compounds has developed from a group of
obscure metabolites of the essential amino acid tryptophan into a source of intensive …

Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …

The kynurenine pathway constitutes the main route of tryptophan degradation and
generates the production of several neuroactive compounds; quinolinic acid is an excitotoxic …

Understanding the neurochemical basis for cognitive function is one of the major goals of
neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range …

The kynurenine pathway is the main pathway for tryptophan metabolism. It generates
compounds that can modulate activity at glutamate receptors and possibly nicotinic …

Tryptophan is an essential amino acid that can be metabolised through different pathways, a
major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2 …

The kynurenine pathway (KP), which is activated in times of stress and infection has been
implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation …