Fungal-induced programmed cell death

TJ Williams, LE Gonzales-Huerta, D Armstrong-James - Journal of Fungi, 2021 - mdpi.com
Fungal infections are a cause of morbidity in humans, and despite the availability of a range
of antifungal treatments, the mortality rate remains unacceptably high. Although our …

[HTML][HTML] Programmed cell death: central player in fungal infections

G Camilli, M Blagojevic, JR Naglik, JP Richardson - Trends in cell biology, 2021 - cell.com
Fungal diseases contribute significantly to morbidity and mortality in humans. Although
recent research has improved our understanding of the complex and dynamic interplay that …

Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens?

PV Stuckey, FH Santiago-Tirado - Infection and Immunity, 2023 - Am Soc Microbiol
Fungal infections represent a major, albeit neglected, public health threat with serious
medical and economic burdens globally. With unacceptably high mortality rates, invasive …

“We've got to get out”—Strategies of human pathogenic fungi to escape from phagocytes

J Sonnberger, L Kasper, T Lange… - Molecular …, 2024 - Wiley Online Library
Human fungal pathogens are a deadly and underappreciated risk to global health that most
severely affect immunocompromised individuals. A virulence attribute shared by some of the …

[HTML][HTML] Programmed cell death in pathogenic fungi

M Ramsdale - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2008 - Elsevier
Greater understanding of programmed cell death (PCD) responses in pathogenic fungi may
offer a chance of exploiting the fungal molecular death machinery to control fungal …

The pathogen Candida albicans hijacks pyroptosis for escape from macrophages

N Uwamahoro, J Verma-Gaur, HH Shen, Y Qu, R Lewis… - MBio, 2014 - Am Soc Microbiol
The fungal pathogen Candida albicans causes macrophage death and escapes, but the
molecular mechanisms remained unknown. Here we used live-cell imaging to monitor the …

[HTML][HTML] A fun-guide to innate immune responses to fungal infections

TB Burgess, AM Condliffe, PM Elks - Journal of Fungi, 2022 - mdpi.com
Immunocompromised individuals are at high risk of developing severe fungal infections with
high mortality rates, while fungal pathogens pose little risk to most healthy people. Poor …

Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans

AJ Phillips, JD Crowe… - Proceedings of the …, 2006 - National Acad Sciences
A better understanding of the molecular basis of programmed cell death (PCD) in fungi
could provide information that is useful in the design of antifungal drugs that combat life …

Host defenses to fungal pathogens

AK Lord, JM Vyas - Clinical Immunology, 2019 - Elsevier
Invasive fungal infections represent a major threat to critically ill and immunocompromised
patients and are associated with significant morbidity and mortality. Aspergillus, Candida …

Targeting intrinsic cell death pathways to control fungal pathogens

M Kulkarni, ZD Stolp, JM Hardwick - Biochemical pharmacology, 2019 - Elsevier
Fungal pathogens pose an increasing threat to public health. Limited clinical drug regimens
and emerging drug-resistant isolates challenge infection control. The global burden of …