Abstract α5 subunit-containing γ-aminobutyric acid type A (GABAA) receptors represent a
promising drug target for neurological and neuropsychiatric disorders. Altered expression …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

Highlights•Several structures of heteromeric αβγ GABA A receptors have recently been
described.•The binding modes of clinically relevant benzodiazepines have been …

The family of GABAA receptors is an important drug target group in the treatment of sleep
disorders, anxiety, epileptic seizures, and many others. The most frequent GABAA receptor …

Many allosteric binding sites that modulate gamma aminobutyric acid (GABA) effects have
been described in heteropentameric GABA type A (GABAA) receptors, among them sites for …

GABA A receptors are ligand-gated ion channels composed of five subunits that can be
opened by GABA and be modulated by multiple pharmacologically and clinically important …

Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …

GABA is the major inhibitory neurotransmitter in the adult mammalian CNS. The ionotropic
GABA type A receptors (GABAARs) belong to the Cys-loop family of receptors. Each …

GABAA receptors have structural and functional homology with a super-family of cys-loop
ligand-gated ion channel receptors including the nicotinic acetylcholine receptors. Amino …

Abstract γ-Aminobutyric acid type A (GABAA) receptors are pentameric GABA-gated chloride
channels that are, in mammalians, drawn from a repertoire of 19 different genes, namely α1 …