Methylation mediated downregulation of TOB1-AS1 and TOB1 correlates with malignant progression and poor prognosis of esophageal squamous cell carcinoma

Z Dong, G Zhang, J Lu, Y Guo, J Liang, S Shen… - Digestive Diseases and …, 2023 - Springer
Background TOB1, a member of the transducer of erbB-2/B-cell translocation gene family,
was detected to be down-regulated in ESCC by RNA sequencing. TOB1-AS1, a head-to …

[HTML][HTML] Phosphorylation of TOB1 at T172 and S320 is critical for gastric cancer proliferation and progression

D Wang, H Song, T Zhao, M Wang… - American Journal of …, 2019 - ncbi.nlm.nih.gov
We previously revealed that increased phosphorylation of TOB1, a tumor suppressor
protein, may promote the progression of gastric cancer. However, the phosphorylated sites …

[HTML][HTML] Prognostic value of transducer of ErbB2. 1 (TOB1) expression in patients with gastric cancer: Tissue microarray analysis

Y Yang, X Shen, K Sun - International Journal of Clinical and …, 2018 - ncbi.nlm.nih.gov
Background: Transducer of ErbB2. 1 (TOB1) protein plays an important role in cell cycle
regulation, apoptosis induction, and metastasis inhibition. However, the prognostic value of …

Promoter hypermethylation-mediated downregulation of tumor suppressor gene SEMA3B and lncRNA SEMA3B-AS1 correlates with progression and prognosis of …

Z Dong, X Liang, X Wu, X Kang, Y Guo, S Shen… - Clinical & experimental …, 2019 - Springer
Frequent deletions of tumor-suppressor genes at chromosome 3p21. 3 have been detected
in esophageal squamous cell carcinoma (ESCC). As a candidate tumor suppressor gene …

[HTML][HTML] Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer

R Guan, L Peng, D Wang, H He, D Wang, R Zhang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
TOB1, a member of the BTG/TOB protein family, inhibits tumor cell proliferation. We
previously observed down-regulation and phosphorylation of TOB1 in gastric cancer (GC) …

The role of DNMT1/hsa-miR-124-3p/BCAT1 pathway in regulating growth and invasion of esophageal squamous cell carcinoma

B Zeng, X Zhang, J Zhao, Z Wei, H Zhu, M Fu, D Zou… - BMC cancer, 2019 - Springer
Background Esophageal squamous cell carcinoma (ESCC) is the major subtype of
esophageal cancer with high aggressiveness and poor prognosis. There is an urgent need …

Clinicopathological significance of cytoplasmic transducer of ErbB2. 1 expression in gastric cancer

SQ Zhang, KK Sun, XY Wu… - Molecular …, 2015 - spandidos-publications.com
The aim of the present study was to investigate the expression of transducer of ErbB2. 1
(TOB1) in gastric carcinoma and to clarify the association between TOB1 expression and the …

[HTML][HTML] Expression and clinical significance of B cell translocation gene 2 in esophageal squamous cell carcinoma

W Wang, H Guo, S Zhou, J Zhu, Y Liu… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Esophageal squamous cell carcinoma (ESCC) is widely known as a highly fatal cancer, and
thus it is important to identify tumor-specific and radiosensitivity-specific markers in ESCC. B …

High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer

D Li, L Xiao, Y Ge, Y Fu, W Zhang, H Cao, B Chen… - Molecular Cancer, 2018 - Springer
Tob1, a Tob/BTG anti-proliferative protein family member, functions as a tumour suppressor
in many cancers. Here, we reveal a unique oncogenic role of Tob1 in colon cancer. Tob1 …

lncRNA BBOX1-AS1 silencing inhibits esophageal squamous cell cancer progression by promoting ferroptosis via miR-513a-3p/SLC7A11 axis

C Pan, G Chen, X Zhao, X Xu, J Liu - European Journal of Pharmacology, 2022 - Elsevier
Long noncoding RNA BBOX1 antisense 1 (BBOX1-AS1) has been demonstrated to play
important roles in several tumors. However, the expression and function of BBOX1-AS1 in …