Protein lipoxidation refers to the modification by electrophilic lipid oxidation products to form
covalent adducts, which for many years has been considered as a deleterious consequence …

Enzymatic and non-enzymatic lipid metabolism can give rise to reactive species that may
covalently modify cellular or plasma proteins through a process known as lipoxidation …

The post‐translational modification of proteins by electrophilic oxylipids is emerging as an
important mechanism that contributes to the complexity of proteomes. Enzymatic and non …

Protein lipoxidation is a non-enzymatic post-translational modification that consists of the
covalent addition of reactive lipid species to proteins. This occurs under basal conditions but …

Lipid oxidation results in the formation of many reactive products, such as small aldehydes,
substituted alkenals, and cyclopentenone prostaglandins, which are all able to form covalent …

Modification of proteins in conditions of oxidative stress can contribute to protein dysfunction
or tissue damage and disease progression. Bifunctional, most often α, β-unsaturated …

Generation of reactive oxygen species and related oxidants is an inevitable consequence of
life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates …

Significance: The systematic investigation of oxidative modification of proteins by reactive
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …

Lipid oxidation is the chemical reaction that most limits shelf life of foods, and it is
increasingly being recognized as a major contributor to oxidative damage in vivo. In foods …

There are a wide variety of reactive species which can affect cell function, including reactive
oxygen, nitrogen, and lipid species. Some are formed endogenously through enzymatic or …