[HTML][HTML] The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex
M Gierula, II Salles‐Crawley, S Santamaria… - Journal of thrombosis …, 2019 - Elsevier
Abstract Background Activated protein C (APC)‐mediated inactivation of factor (F) Va is
greatly enhanced by protein S. For inactivation to occur, a trimolecular complex among FVa …
greatly enhanced by protein S. For inactivation to occur, a trimolecular complex among FVa …
[HTML][HTML] Novel APC‐cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S
S Tran, B Dahlbäck - Journal of Thrombosis and Haemostasis, 2010 - Elsevier
Summary Background: Activated protein C (APC) inhibits factor Va (FVa) by cleaving at
Arg306, Arg506 and Arg679. Protein S serves as cofactor, in particular for the Arg306 site …
Arg306, Arg506 and Arg679. Protein S serves as cofactor, in particular for the Arg306 site …
Factor V and protein S as cofactors to activated protein C
B Dahlback - Haematologica, 1997 - haematologica.org
BACKGROUND AND OBJECTIVE: Activated protein C (APC)-resistance, the most common
risk factor for venous thrombosis described so far, is due to a single point mutation in the …
risk factor for venous thrombosis described so far, is due to a single point mutation in the …
C4b-binding protein protects coagulation factor Va from inactivation by activated protein C
RHL van de Poel, JCM Meijers, J Rosing, G Tans… - Biochemistry, 2000 - ACS Publications
We investigated the effect of C4BP on APC-mediated inactivation of factor Va (FVa) in the
absence and presence of protein S. FVa inactivation was biphasic (k 506= 4.4× 108 M-1 s-1 …
absence and presence of protein S. FVa inactivation was biphasic (k 506= 4.4× 108 M-1 s-1 …
Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va
EA Norstrøm, M Steen, S Tran, B Dahlbäck - Journal of Biological …, 2003 - ASBMB
The procoagulant function of activated factor V (FVa) is inhibited by activated protein C
(APC) through proteolytic cleavages at Arg 306, Arg 506, and Arg 679. The effect of APC is …
(APC) through proteolytic cleavages at Arg 306, Arg 506, and Arg 679. The effect of APC is …
C4b-binding protein inhibits the factor V-dependent but not the factor V-independent cofactor activity of protein S in the activated protein C-mediated inactivation of …
RHL van de Poel, JCM Meijers… - Thrombosis and …, 2001 - thieme-connect.com
Activated protein C (APC) is an important inactivator of coagulation factors Va and VIIIa. In
the inactivation of factors Va and VIIIa, protein S serves as a cofactor to APC. Protein S can …
the inactivation of factors Va and VIIIa, protein S serves as a cofactor to APC. Protein S can …
Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va
TJ Cramer, JH Griffin, AJ Gale - Pathophysiology of haemostasis and …, 2010 - karger.com
Coagulation factor V (FV) promotes inactivation of activated factor VIII (FVIIIa) by activated
protein C (APC) and protein S. Loss of this APC cofactor activity is proposed to be partially …
protein C (APC) and protein S. Loss of this APC cofactor activity is proposed to be partially …
Kinetics of inactivation of membrane-bound factor Va by activated protein C. Protein S modulates factor Xa protection.
S Solymoss, MM Tucker, PB Tracy - Journal of Biological Chemistry, 1988 - Elsevier
Kinetic analyses were done to determine what effect factor Xa and protein S had on the
activated protein C (APC)-catalyzed inactivation of factor Va bound to phospholipid vesicles …
activated protein C (APC)-catalyzed inactivation of factor Va bound to phospholipid vesicles …
Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin
K Segers, B Dahlback, J Rosing… - Journal of biological …, 2008 - ASBMB
Inactivation of factor Va (FVa) by activated protein C (APC) is a key reaction in the down-
regulation of thrombin formation. FVa inactivation by APC is correlated with a loss of FXa …
regulation of thrombin formation. FVa inactivation by APC is correlated with a loss of FXa …
Factor Va residues 311–325 represent an activated protein C binding region
S Yegneswaran, Y Kojima, PM Nguyen, AJ Gale… - Journal of biological …, 2007 - ASBMB
Activated protein C (APC) inactivates factor Va (fVa) by proteolytically cleaving fVa heavy
chain at Arg 506, Arg 306, and Arg 679. Factor Xa (fXa) protects fVa from inactivation by …
chain at Arg 506, Arg 306, and Arg 679. Factor Xa (fXa) protects fVa from inactivation by …