The long pentraxin (PTX) 3 is produced by macrophages and myeloid dendritic cells in
response to Toll-like receptor agonists and represents a nonredundant component of …

The innate immune system consists of a cellular arm and a humoral arm. Components of
humoral immunity include diverse molecular families, which represent functional ancestors …

Pentraxins are a superfamily of conserved proteins involved in the acute-phase response
and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin …

PTX3 is a prototypic of long pentraxin consisting of an N‐terminal portion coupled to a C‐
terminal pentraxin domain, the latter related to short pentraxins (C‐reactive protein and …

Pentraxins are a complex superfamily of multifunctional molecules characterized by a
multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of …

Pentraxins are soluble pattern recognition receptors with a dual role: protection against
extracellular microbes and autoimmunity. The mechanisms by which they accomplish these …

The protopypic long pentraxin 3 (PTX3) is a unique, humoral pattern-recognition receptor,
which plays a nonredundant function in innate resistance to pathogens. Dendritic cells (DC) …

Pattern recognition molecules (PRMs) are components of the humoral arm of innate
immunity; they recognize pathogen‐associated molecular patterns (PAMP) and are …

Pentraxin 3 (PTX3) is the first long pentraxin identified. Long pentraxins consist of a C-
terminal pentraxin domain, which has sequence similarity to C-reactive protein (CRP) and …

Pentraxins are acute-phase proteins produced in vivo during inflammatory reactions.
Classical short pentraxins, C-reactive protein, and serum amyloid P component are …