Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

The protein kinase family represents an enormous opportunity for drug development.
However, the current limitation in structural diversity of kinase inhibitors has complicated …

Imidazo[1,2-a]pyrazines as novel PI3K inhibitors - ScienceDirect Skip to main contentSkip to
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The novel imidazo [4, 5-c] pyridine 1, 2, 5-oxadiazol-3-yl template affords an excellent start
point for identification of inhibitors of a number of protein kinases. Here we report on its …

Pyrazolo [3, 4-d] pyrimidines have become of significant interest for the medicinal chemistry
community as a privileged scaffold for the development of kinase inhibitors to treat a range …

Phosphatidylinositol 3-kinase α (PI3Kα) is an important regulator of intracellular signaling
pathways, controlling remarkably diverse arrays of physiological processes. Because the …

Chemotherapy is a type of cancer treatment that uses a systemic drug to kill cancer cells
wherever it finds in the body. It implements their actions through intervention with molecular …

We have identified a novel structural class of protein serine/threonine kinase inhibitors
comprised of an aminoimidazo [1, 2-a] pyridine nucleus. Compounds from this family are …

Imidazo [4, 5-c] quinoline derivatives have been discovered and developed as potent and
effective modulators of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) …

Abstract Alterations in PI3K/AKT signaling are known to be implicated with tumorigenesis.
The PI3 kinases family of lipid kinases has been an attractive therapeutic target for cancer …