The structure–pharmacological activity relationships generally accepted for antitumor
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …

It has been shown recently that some analogues of clinically ineffective trans-
diamminedichloroplatinum (II)(transplatin) exhibit antitumor activity. This finding has inverted …

Recent findings that novel trans-dichloroplatinum (II) complexes exhibit antitumor activity
violate the classical structure-activity relationships of platinum (II) complexes. These novel …

Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2 (E-
iminoether) 2], exhibits antitumor activity has helped reevaluation of the empirical structure …

A paradigm for the structure-pharmacological activity relationship of bifunctional platinum
antitumor drugs is that the trans isomer of antitumor cisplatin (transplatin) is clinically …

Abstract Bis (platinum) complexes [{cis-PtCl2 (NH3)} 2H2N (CH2) nNH2] are a novel series
of potential anticancer agents in which two cis-diamine (platinum) groups are linked by an …

The global modification of mammalian and plasmid DNAs by novel platinum compounds,
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …

Recent observations that several trans‐platinum complexes exhibit antitumor activity
including activity in cisplatin‐resistant tumor cells, violates the classical structure/activity …

Antitumor effects of cis-diamminedichloroplatinum (II)(cisplatin) and the clinical inactivity of
its trans isomer (transplatin) have been considered a paradigm for the classical structure …

Revised Manuscript Received July 20, 1990 abstract: The properties of a new bis (platinum)
complex containingtwo monodentate coordination spheres,[{tra «5-PtCl (NH3) 2j2H2N …