Multi-omics analysis reveals the unexpected immune regulatory effects of arsenene nanosheets in tumor microenvironment

X Wang, J Zhang, Y Hu, X Zhao, Z Wang… - … Applied Materials & …, 2022 - ACS Publications
Arsenene, a two-dimensional (2D) monoelemental layered nanosheet composed of arsenic,
was recently reported to feature outstanding anticancer activities. However, the specific …

PSMA-targeted arsenic nanosheets: a platform for prostate cancer therapy via ferroptosis and ATM deficiency-triggered chemosensitization

H Wang, L Zhang, Z Miao, M Zhang, H Liu, Q He… - Materials …, 2021 - pubs.rsc.org
Ferroptosis, a newly recognized form of non-apoptotic cell death, has recently been
introduced for effective cancer therapy. The reported ferroptosis-inducing nanomaterials …

Arsenene: a potential therapeutic agent for acute promyelocytic leukaemia cells by acting on nuclear proteins

X Wang, Y Hu, J Mo, J Zhang, Z Wang… - Angewandte …, 2020 - Wiley Online Library
Arsenene has recently emerged as a promising new two‐dimensional material for
biomedical applications because of its excellent optical and electronic properties. Herein …

DNA damage-encouraged Mn-As-based nanoreactors reshape intratumoral cell phenotypes to recover immune surveillance and potentiate anti-tumor immunity

Q Zhao, X Dong, C Zhu, Y Zhang, C Fang… - Chemical Engineering …, 2023 - Elsevier
Arsenic trioxide is a promising anti-tumor approach based on cytotoxic reactive oxygen
species (ROS). However, the harsh post-encapsulation conditions, complex tumor …

Reactive oxygen species-sensitive biodegradable mesoporous silica nanoparticles harboring TheraVac elicit tumor-specific immunity for colon tumor treatment

Y Huang, S Nahar, MDM Alam, S Hu, DW McVicar… - ACS …, 2023 - ACS Publications
Immunotherapy has revolutionized the field of cancer treatment through invigorating robust
antitumor immune response. Here, we report the development of a thera peutic vac cine …

Anti-Her2 affibody-decorated arsenene nanosheets induce ferroptosis through depleting intracellular GSH to overcome cisplatin resistance

P He, S Xu, Z Miao, Y Que, Y Chen, S Li, Q Ma… - Journal of …, 2023 - Springer
Ferroptosis, a form of regulated cell death induced by excessive accumulation of reactive
oxygen species and lipid peroxidation, has recently attracted extensive attention due to its …

Engineering bioinspired nanomedicines to mitigate the resistance to cancer immunotherapy

J Ye, B Hou, M Saeed, Z Xu, H Yu - Accounts of Materials …, 2022 - ACS Publications
Conspectus The current era has witnessed the success of immunotherapy, in particular,
immune checkpoint blockade (ICB) therapy, at an unprecedented pace. However …

Arsenic nano complex induced degradation of YAP sensitized ESCC cancer cells to radiation and chemotherapy

W Zhou, M Liu, X Li, P Zhang, J Li, Y Zhao, G Sun… - Cell & Bioscience, 2020 - Springer
Background Increased reactive oxygen species (ROS) production by arsenic treatment in
solid tumors showed to be effective to sensitize cancer cells to chemotherapies. Arsenic …

Emerging landscapes of nanosystems based on pre-metastatic microenvironment for cancer theranostics

Y Chu, T Sun, C Jiang - Chinese Chemical Letters, 2022 - Elsevier
The emergence of disseminated metastasis is the leading cause of mortality in patients with
malignant tumor. The pre-metastatic microenvironment, including the primary tumor-derived …

Multifunctional redox-responsive nanoplatform with Dual Activation of Macrophages and T Cells for Antitumor Immunotherapy

W Zhang, X Liu, S Cao, Q Zhang, X Chen, W Luo… - ACS …, 2023 - ACS Publications
High expression of programmed death ligand 1 (PD-L1) and strong immune evasion ability
of the tumor microenvironment (TME) are maintained through mutual regulation between …