Objectives: The worldwide spread of Parkinson's disease (PD) calls for sensitive and
specific measures enabling its early (or, ideally, preclinical) detection. Here, we use …

The purpose of this study was to identify differences between genetically undefined (GU)
early-onset Parkinson's disease (EOPD) patients and carriers of Parkin mutations on non …

Cognitive impairment is common in idiopathic Parkinson's disease (PD). Knowledge of the
contribution of genetics to cognition in PD is increasing in the last decades. Monogenic …

Parkinson's disease is a frequent neurodegenerative disease that is mostly known for its
motor symptoms. However, cognitive impairment is now recognised as an important part of …

Background: Patients with Parkinson's disease (PD) have cognitive changes resulting,
presumably, from a progressive disruption of the functional integrity of frontostriatal circuitry …

Cognitive impairments are prevalent in patients with Parkinson's disease. Mutations in the
leucine‐rich repeat kinase 2 (LRRK 2) gene are the most common cause of genetic …

The current pathologic criteria for idiopathic Parkinson's disease (iPD) require both neuronal
loss in the substantia nigra pars compacta (SNpc) and alpha-synuclein–containing Lewy …

Embodied cognition research on Parkinson's disease (PD) points to disruptions of
frontostriatal language functions as sensitive targets for clinical assessment. However, no …

We have established that the frequency of LRRK2 mutations in a series of 118 cases of
familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late …

Importance Data on the long-term cognitive outcomes of patients withPARKIN-associated
Parkinson disease (PD) are unknown but may be useful when counseling these patients …