[HTML][HTML] Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
T Saarelainen, P Hendolin, G Lucas… - Journal of …, 2003 - Soc Neuroscience
Recent studies have indicated that exogenously administered neurotrophins produce
antidepressant-like behavioral effects. We have here investigated the role of endogenous …
antidepressant-like behavioral effects. We have here investigated the role of endogenous …
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade
Background Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived
neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this …
neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this …
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cγ signaling pathways in …
T Rantamäki, P Hendolin, A Kankaanpää… - …, 2007 - nature.com
Previous studies suggest that brain-derived neurotrophic factor and its receptor TrkB are
critically involved in the therapeutic actions of antidepressant drugs. We have previously …
critically involved in the therapeutic actions of antidepressant drugs. We have previously …
BDNF receptor TrkB as the mediator of the antidepressant drug action
Brain-derived neurotrophic factor (BDNF) signaling through its receptor TrkB has for a long
time been recognized as a critical mediator of the antidepressant drug action, but BDNF …
time been recognized as a critical mediator of the antidepressant drug action, but BDNF …
Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines.
E Koponen, T Rantamäki, V Voikar… - Cellular and …, 2005 - europepmc.org
1. Neurotrophins and serotonin have both been implicated in the pathophysiology of
depression and in the mechanisms of antidepressant treatments. 2. Brain-derived …
depression and in the mechanisms of antidepressant treatments. 2. Brain-derived …
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
R Moliner, M Girych, CA Brunello, V Kovaleva… - Nature …, 2023 - nature.com
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …
resembling the effects of clinically approved antidepressants. We recently reported that …
Neuronal plasticity and neurotrophic factors in drug responses
Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …
[HTML][HTML] Brain-derived neurotrophic factor signaling in depression and antidepressant action
E Castrén, LM Monteggia - Biological psychiatry, 2021 - Elsevier
Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …
associated with depression and antidepressant drug action. A variety of preclinical and …
Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”
BACKGROUND: According to the neurotrophin hypothesis of depression, decreased activity
of brain-derived neurotrophic factor (BDNF) contributes to behavioral and plasticity-related …
of brain-derived neurotrophic factor (BDNF) contributes to behavioral and plasticity-related …