A progressive cholangiofibrosis was developed as an animal model in 6-week-old male
F344 rats by repeated intraperitoneal injections of α-naphthylisothiocyanate (ANIT) for 19 …

To investigate pathogenesis of post–bile duct (BD) injury fibrosis, interlobular BD epithelial
injury was induced in male F344 rats by a single IP injection of α-naphthylisothiocyanate (75 …

Biliary fibrosis is a complex process in which macrophages and myofibroblasts may play
central roles. We investigated biliary fibrosis lesions induced in the Glisson's sheath in rats …

Exposure of rodents to the xenobiotic α‐naphthylisothiocyanate (ANIT) is an established
model of experimental intrahepatic bile duct injury. Administration of ANIT to mice causes …

These studies were designed to evaluate ANIT-induced changes in both hepatobiliary
function and morphology during the onset, progression, and recovery of ANIT-induced …

Biliary Epithelial Cell Proliferation Following α-Naphthylisothiocyanate (ANIT) Treatment:
Relationship to Bile Duct Obstruction. Kossor, DC, Goldstein, RS, Ngo, W., DeNicola, D, B …

Morphological changes in bile duct lining cells precede morphological changes in
hepatocytes in rats treated with 300 mg/kg body wt of α-naphthylisothiocyanate (ANIT). Four …

Two known cholangiotoxic agents, alpha-naphthylisothiocyanate (ANIT) and p-
phenylenediisothiocyanate (PDT), were administered in single doses to mice to study their …

alpha-Naphthylisothiocyanate (ANIT) causes cholestasis and injury to bile duct epithelium
and hepatic parenchymal cells in rats. The mechanism of toxicity is unknown. Neutrophils …

1-Naphthylisothiocyanate (ANIT) produces cholangiolitic hepatitis in rats. This injury is
characterized by periportal bile duct and hepatic parenchymal cell necrosis with …