Leptin is a hormone secreted by adipocytes that regulates energy metabolism via peripheral
action on glucose synthesis and utilization as well as through central regulation of food …

Leptin, an adipocyte-secreted hormone, regulates energy homeostasis as well as
reproductive, neuroendocrine, immune and metabolic functions. Subjects with decreased …

Lipodystrophy is a clinically heterogeneous group of disorders characterized by abnormal
adipose tissue metabolism, which is almost always complicated by metabolic …

Context: Leptin deficiency is associated with dyslipidemia and insulin resistance in animals
and humans with lipoatrophy; leptin replacement ameliorates these abnormalities …

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

Leptin in the form of recombinant human methionyl leptin (metreleptin) has now been
approved by the FDA for treatment of generalized forms of lipodystrophy. Leptin deficiency …

The most common form of partial, acquired lipodystrophy is the HIV-associated
lipodystrophy syndrome (HALS), which was first reported 11 yr ago (1, 2). The prevalence of …

Background The adipocyte hormone leptin is important in regulating energy homeostasis.
Since severe lipodystrophy is associated with leptin deficiency, insulin resistance …

Objective To review evidence supporting the hypothesis that metabolic manifestations of
lipodystrophy result from leptin deficiency and that leptin replacement may be a viable …

Aims/hypothesis Lipodystrophy is a rare disorder characterised by loss of adipose tissue,
hypoleptinaemia, severe insulin resistance, diabetes and dyslipidaemia. The aims of this …