This work presents results of in vivo and in situ measurements of hepatocellular carcinoma
by a developed optical biopsy system. Here, we describe the technical details of the …

A biopsy is often performed for the diagnosis of cancer during a surgical operation. In
addition, pathological biopsy is required to discriminate the margin between cancer tissues …

The intrinsic NADH autofluorescence intensity of biological tissue depends on the local,
cellular concentration of this coenzyme. It plays a dominant role in the Krebs-Cycle and …

This paper presents the results of the experiments which were performed using the optical
biopsy system specially developed for in vivo tissue classification during the percutaneous …

We investigated differences between healthy tissue and metastatic tumor from ex vivo
human partial liver resections using diffuse optical spectroscopy with a fiber optic probe. We …

The Time-resolved fluorescence spectroscopy (TR-FS) has the potential to differentiate
tumor and normal tissue in real time during surgical excision. In this manuscript, we describe …

Although fluorescence lifetime imaging microscopy (FLIM) has been extensively applied to
study cellular metabolism in the liver, there is neither an established approach to analyze …

THE AUTHORS BRIEFLY HIGHLIGHT OPTICAL TECHNIQUES AVAILABLE FOR
BIODIAGNOSTICS, DESCRIBE THE DIFFICULTY OF TISSUE SCATTERING WHICH LIMITS …

Autofluorescence emission of liver tissue depends on the presence of endogenous
biomolecules able to fluoresce under suitable light excitation. Overall autofluorescence …

Optical measurements of metabolism are ideally acquired in vivo; however, intravital
measurements are often impractical. Accurate ex vivo assessments would greatly broaden …