Bioprinting and differentiation of adipose-derived stromal cell spheroids for a 3D breast cancer-adipose tissue model

H Horder, M Guaza Lasheras, N Grummel… - Cells, 2021 - mdpi.com
Biofabrication, including printing technologies, has emerged as a powerful approach to the
design of disease models, such as in cancer research. In breast cancer, adipose tissue has …

Bioprinted three-dimensional cell-laden hydrogels to evaluate adipocyte-breast cancer cell interactions

S Chaji, J Al-Saleh, CT Gomillion - Gels, 2020 - mdpi.com
Three-dimensional (3D) bioprinting, although still in its infancy as a fabrication tool, has the
potential to effectively mimic many biological environments. Cell-laden 3D printed structures …

Bioprinting predifferentiated adipose-derived mesenchymal stem cell spheroids with methacrylated gelatin ink for adipose tissue engineering

J Colle, P Blondeel, A De Bruyne, S Bochar… - Journal of Materials …, 2020 - Springer
The increasing number of mastectomies results in a greater demand for breast
reconstruction characterized by simplicity and a low complication profile. Reconstructive …

An Engineered Human Adipose/Collagen Model for In Vitro Breast Cancer Cell Migration Studies

RD Hume, L Berry, S Reichelt, M D'Angelo… - … Engineering Part A, 2018 - liebertpub.com
Adipocytes are one of the major stromal cell components of the human breast. These cells
play a key role in the development of the gland and are implicated in breast tumorigenesis …

High‐throughput fabrication of vascularized adipose microtissues for 3D bioprinting

L Benmeridja, L De Moor, E De Maere… - Journal of Tissue …, 2020 - Wiley Online Library
For patients with soft tissue defects, repair with autologous in vitro engineered adipose
tissue could be a promising alternative to current surgical therapies. A volume‐persistent …

Bioprinting of 3D breast epithelial spheroids for human cancer models

S Swaminathan, Q Hamid, W Sun, AM Clyne - Biofabrication, 2019 - iopscience.iop.org
Abstract 3D human cancer models provide a better platform for drug efficacy studies than
conventional 2D culture, since they recapitulate important aspects of the in vivo …

Laser direct-write based fabrication of a spatially-defined, biomimetic construct as a potential model for breast cancer cell invasion into adipose tissue

BT Vinson, TB Phamduy, J Shipman, B Riggs… - …, 2017 - iopscience.iop.org
Epithelial-adipose interaction is an integral step in breast cancer cell invasion and
progression towards lethal metastatic disease. Understanding the physiological contribution …

Engineering densely packed adipose tissue via environmentally controlled in‐bath 3D Bioprinting

M Ahn, WW Cho, BS Kim… - Advanced Functional …, 2022 - Wiley Online Library
The adipose tissue is a crucial endocrine organ that coordinates with other organs, playing a
key role in metabolic regulation. However, it remains challenging to recreate the morphology …

A complex 3D human tissue culture system based on mammary stromal cells and silk scaffolds for modeling breast morphogenesis and function

X Wang, L Sun, MV Maffini, A Soto, C Sonnenschein… - Biomaterials, 2010 - Elsevier
Epithelial-stromal interactions play a crucial role in normal embryonic development and
carcinogenesis of the human breast while the underlying mechanisms of these events …

3D bioprinting of breast cancer models for drug resistance study

Y Wang, W Shi, M Kuss, S Mirza, D Qi… - ACS biomaterials …, 2018 - ACS Publications
Adipose-derived mesenchymal stem/stromal cells (ADMSC) are one of the major stromal
cells in the breast cancer microenvironment that promote cancer progression. Previous …