Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

AA Date, J Hanes, LM Ensign - Journal of Controlled Release, 2016 - Elsevier
The oral route is a preferred method of drug administration, though achieving effective drug
delivery and minimizing off-target side effects is often challenging. Formulation into …

In vitro and in vivo models for the study of oral delivery of nanoparticles

JM Gamboa, KW Leong - Advanced drug delivery reviews, 2013 - Elsevier
Oral delivery is an attractive route to deliver therapeutics via nanoparticles due to its ease of
administration and patient compliance. This review discusses laboratory techniques for …

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

A Banerjee, J Qi, R Gogoi, J Wong… - Journal of Controlled …, 2016 - Elsevier
Nanoparticles find intriguing applications in oral drug delivery since they present a large
surface area for interactions with the gastrointestinal tract and can be modified in various …

Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers

LM Ensign, R Cone, J Hanes - Advanced drug delivery reviews, 2012 - Elsevier
Oral delivery is the most common method for drug administration. However, poor solubility,
stability, and bioavailability of many drugs make achieving therapeutic levels via the …

[HTML][HTML] Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives

S Asad, AC Jacobsen, A Teleki - Current Opinion in Chemical Engineering, 2022 - Elsevier
Oral delivery is the preferred route of drug administration due to patient compliance and
convenience. Despite this, nanomedicines have so far primarily been developed for the …

Polymeric nanoparticle drug delivery technologies for oral delivery applications

EM Pridgen, F Alexis, OC Farokhzad - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Many therapeutics are limited to parenteral administration. Oral administration
is a desirable alternative because of the convenience and increased compliance by …

Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective

SA Ejazi, R Louisthelmy, K Maisel - ACS nano, 2023 - ACS Publications
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …

Nanoparticle-based oral drug delivery systems targeting the colon for treatment of ulcerative colitis

M Zhang, D Merlin - Inflammatory bowel diseases, 2018 - academic.oup.com
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is characterized by chronic relapsing inflammation of the gastrointestinal tract. Delivery …

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

Polymeric nanoparticle technologies for oral drug delivery

EM Pridgen, F Alexis, OC Farokhzad - Clinical Gastroenterology and …, 2014 - Elsevier
Biologics increasingly are being used for the treatment of many diseases. These treatments
typically require repeated doses administered by injection. Alternate routes of …