Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Background—Histone deacetylase 3 (HDAC3) is known to play a crucial role in the
differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells …

Background: Clinical studies show that the most common single-point mutation in humans,
ALDH2 (aldehyde dehydrogenase 2) rs671 mutation, is a risk factor for the development and …

Background Aortic dissection is a severe inflammatory vascular disease with high mortality
and limited therapeutic options. The hallmarks of aortic dissection comprise aortic …

The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …

Background: Cardiac hypertrophy is an important prepathology of, and will ultimately lead to,
heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain …

Background—Coronary spastic angina (CSA) is a common disease among East Asians,
including Japanese. The prevalence of alcohol flushing syndrome associated with deficient …

Objective—Arginase 2 (Arg2) is a critical target in atherosclerosis because it controls
endothelial nitric oxide, proliferation, fibrosis, and inflammation. Regulators of Arg2 …

The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …