BMSC‐Derived Exosomes Alleviate Sepsis‐Associated Acute Respiratory Distress Syndrome by Activating the Nrf2 Pathway to Reverse Mitochondrial Dysfunction

Z Li, B Zheng, C Liu, X Zhao, Y Zhao… - Stem Cells …, 2023 - Wiley Online Library
Type II alveolar epithelial cell (AECII) apoptosis is one of the most vital causes of sepsis‐
induced acute respiratory distress syndrome (ARDS). Recent evidence has proved that …

[HTML][HTML] AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

L Xia, C Zhang, N Lv, Z Liang, T Ma, H Cheng, Y Xia… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be
associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived …

Mesenchymal stem cells-derived exosomes alleviate acute lung injury by inhibiting alveolar macrophage pyroptosis

P Liu, S Yang, X Shao, C Li, Z Wang… - Stem Cells …, 2024 - academic.oup.com
Acute lung injury (ALI) is an important pathological process of acute respiratory distress
syndrome, yet there are limited therapies for its treatment. Mesenchymal stem cells-derived …

BMSC‐derived exosomes ameliorate LPS‐induced acute lung injury by miR‐384‐5p‐controlled alveolar macrophage autophagy

X Liu, C Gao, Y Wang, L Niu, S Jiang… - Oxidative Medicine and …, 2021 - Wiley Online Library
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common critical
diseases. Bone marrow mesenchymal stem cell (BMSC) transplantation is previously shown …

BMMSC-derived exosomes attenuate cardiopulmonary bypass-related acute lung injury by reducing inflammatory response and oxidative stress

TY Zhang, H Zhang, JY Deng, HR Gong… - Current stem cell …, 2023 - ingentaconnect.com
Background: Acute lung injury (ALI), which is characterized by inflammation and oxidative
stress, is a common complication after cardiopulmonary bypass (CPB). Exosomes from bone …

Mitigation of sepsis-induced acute lung injury by BMSC-derived exosomal miR-125b-5p through STAT3-mediated suppression of macrophage pyroptosis

Y Tao, X Xu, B Yang, H Zhao, Y Li - International Journal of …, 2023 - Taylor & Francis
Introduction Sepsis is a syndrome characterized by high morbidity and mortality rates. One
of its most severe complications is acute lung injury, which exhibits a multitude of clinical …

IL-1β-pretreated bone mesenchymal stem cell-derived exosomes alleviate septic endoplasmic reticulum stress via regulating SIRT1/ERK pathway

X Cheng, S Wang, Z Li, D He, J Wu, W Ding - Heliyon, 2023 - cell.com
Background Endoplasmic reticulum (ER) plays a crucial role in the development of organ
injury caused by sepsis. Therefore, it is highly important to devise strategies that specially …

Differential Lung Protective Capacity of Exosomes Derived from Human Adipose Tissue, Bone Marrow, and Umbilical Cord Mesenchymal Stem Cells in Sepsis …

H Deng, L Zhu, Y Zhang, L Zheng, S Hu… - Oxidative medicine …, 2022 - Wiley Online Library
Exosomes derived from human mesenchymal stem cells (hMSCs) have the capacity to
regulate various biological events associated with sepsis‐induced acute respiratory distress …

Bone mesenchymal stem cell-derived exosomes prevent hyperoxia-induced apoptosis of primary type II alveolar epithelial cells in vitro

W Yang, C Huang, W Wang, B Zhang, Y Chen, X Xie - PeerJ, 2022 - peerj.com
Background The presence of alveolar epithelial type II cells (AECIIs) is one of the most
important causes of bronchopulmonary dysplasia (BPD). Exosomes from bone …

Exosome from BMMSC attenuates cardiopulmonary bypass-induced acute lung injury via YAP/β-catenin pathway: downregulation of pyroptosis

T Zhang, L Lu, M Li, D Zhang, P Yu, X Zhang… - Stem Cells, 2022 - academic.oup.com
Acute lung injury (ALI) accompanied with systemic inflammatory response is an important
complication after cardiopulmonary bypass (CPB). Pyroptosis, which is induced by the …