Allograft loss remains a severe clinical problem after kidney transplantation. The molecular
mechanism of graft loss is a complex process involving T and/or B cell activation …

Kidney transplantation represents the therapy of choice for many patients with end-stage
renal disease. However, the success of renal engraftment is hindered by a number of …

Kidney transplantation remains the best therapeutic option for patients with end-stage renal
disease. Immunosuppressive therapy has largely resolved the issue of acute transplant …

One major complication facing organ transplant recipients is the requirement for life-long
systemic immunosuppression to prevent rejection, which is associated with an increased …

Organ transplantation represents the only definitive therapy for many causes of end‐organ
failure. However, the universal success of this therapy is limited by chronic allograft …

Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has
been successfully applied in the last decade to ameliorate the renal function compromised …

A number of renal pathologies exist that have seen little or no improvement in treatment
methods over the past 20 years. These pathologies include acute and chronic kidney …

Gene therapy is an exciting and novel technology that offers the prospect of improving
transplant outcomes beyond those achievable with current clinical protocols. This review …

Organ transplantation represents the only possible therapeutic intervention for a large
number of end-stage renal diseases. The current immunosuppressive drugs are very …

Despite the impressive results of one-year survival rates, organ transplantation still faces
major problems. Current anti-rejection drugs reduce systemic immunity nonselectively and …