Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Background: The first tubulin targeting agents were approved as cancer chemotherapeutics
over 40 years ago and tubulin as an antitumor target continues to attract significant drug …

Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …

Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Introduction: Microtubules play an important role in several cellular processes, particularly in
the formation of the mitotic spindle during the process of mitosis. These highly dynamic …

Anticancer drugs directed against the microtubule, including taxanes and vinca alkaloids,
have been the backbone of many chemotherapy regimes for decades. These drugs have …

Introduction: About 20 patents have been published from 2013 to 2018 for developing
advanced cancer therapeutics by targeting tubulin polymerization. Currently, there are …

Paclitaxel, docetaxel and vinca alkaloids like vinblastine are compounds interacting with the
mitotic spindle by binding to β-tubulin. They are used as therapeutics in standard …