Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

This new edition of Animal Models in Cardiovascular Research describes historical and
recent advances in our understanding of the cardiovascular system from studies conducted …

It was only≈ 15 years ago that methodologies evolved to the point where we began to
manipulate the genetic apparatus of the mouse such that proteins of the investigator's choice …

To improve human health, scientific discoveries must be translated into practical
applications. Inherent in the development of these technologies is the role of preclinical …

There is an urgent clinical need to develop new therapeutic approaches for treating
cardiovascular disease, but the biology of cardiovascular regeneration is complex. Model …

Animal models that mimic cardiovascular diseases are indispensable tools for
understanding the mechanisms underlying the diseases at the cellular and molecular level …

The human cardiovascular system is a complex arrangement of specialized structures with
distinct functions. The molecular landscape, including the genome, transcriptome and …

The mouse is a proven model for studying human disease. Many strains exist that exhibit
either natural or engineered genetic variation and thereby enable the elucidation of …

The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …

Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …