[HTML][HTML] Heterogeneity of white adipose tissue: molecular basis and clinical implications

KHM Kwok, KSL Lam, A Xu - Experimental & molecular medicine, 2016 - nature.com
Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

[HTML][HTML] Sex dimorphism and depot differences in adipose tissue function

UA White, YD Tchoukalova - … et Biophysica Acta (BBA)-Molecular Basis of …, 2014 - Elsevier
Obesity, characterized by excessive adiposity, is a risk factor for many metabolic
pathologies, such as type 2 diabetes mellitus (T2DM). Numerous studies have shown that …

Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications

MJ Lee, Y Wu, SK Fried - Molecular aspects of medicine, 2013 - Elsevier
Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as
type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat …

Obesity phenotypes: depot-differences in adipose tissue and their clinical implications

V Guglielmi, P Sbraccia - Eating and weight Disorders-Studies on …, 2018 - Springer
Obesity, defined as excess fat mass, increases risks for multiple chronic diseases, such as
type 2 diabetes, cardiovascular disease, and several types of cancer. Beyond adiposity per …

Deciphering adipose tissue heterogeneity

MD Lynes, YH Tseng - Annals of the New York Academy of …, 2018 - Wiley Online Library
Obesity is an excess accumulation of adipose tissue mass, and, together with its sequelae,
in particular type II diabetes and metabolic syndrome, obesity presents a major health crisis …

[HTML][HTML] Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

CR Kahn, G Wang, KY Lee - The Journal of clinical …, 2019 - Am Soc Clin Investig
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

Brown adipose tissue: mechanisms and potential therapeutic targets

CS Tam, V Lecoultre, E Ravussin - Circulation, 2012 - Am Heart Assoc
Obesity is a significant health challenge, with the latest projections estimating that there will
be 2.16 billion overweight and 1.12 billion obese individuals globally by 2030. In addition to …

[HTML][HTML] Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy

X Ma, P Lee, DJ Chisholm, DE James - Frontiers in endocrinology, 2015 - frontiersin.org
Adipocyte differentiation and its impact on restriction or expansion of particular adipose
tissue depots have physiological and pathophysiological significance in view of the different …

The role of adipose tissue in cardiovascular health and disease

EK Oikonomou, C Antoniades - Nature Reviews Cardiology, 2019 - nature.com
Accumulating knowledge on the biology and function of the adipose tissue has led to a
major shift in our understanding of its role in health and disease. The adipose tissue is now …

Heterogeneity of adipose tissue in development and metabolic function

T Schoettl, IP Fischer, S Ussar - Journal of Experimental …, 2018 - journals.biologists.com
Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These …