Proteomics elucidating physiological and pathological functions of TDP‐43

J García Morato, CJ Gloeckner, PJ Kahle - Proteomics, 2023 - Wiley Online Library
Trans‐activation response DNA binding protein of 43 kDa (TDP‐43) regulates a great
variety of cellular processes in the nucleus and cytosol. In addition, a defined subset of …

TDP‐43 regulates its mRNA levels through a negative feedback loop

YM Ayala, L De Conti, SE Avendaño‐Vázquez… - The EMBO …, 2011 - embopress.org
TAR DNA‐binding protein (TDP‐43) is an evolutionarily conserved heterogeneous nuclear
ribonucleoprotein (hnRNP) involved in RNA processing, whose abnormal cellular …

TDP43 ribonucleoprotein granules: physiologic function to pathologic aggregates

GA Corbet, JR Wheeler, R Parker, K Weskamp - RNA biology, 2021 - Taylor & Francis
Ribonucleoprotein (RNP) assemblies are ubiquitous in eukaryotic cells and have functions
throughout RNA transcription, splicing, and stability. Of the RNA-binding proteins that form …

RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo

NM Scherer, C Maurel, MS Graus… - Nucleic Acids …, 2024 - academic.oup.com
Insoluble cytoplasmic aggregate formation of the RNA-binding protein TDP-43 is a major
hallmark of neurodegenerative diseases including Amyotrophic Lateral Sclerosis. TDP-43 …

Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport

M Štalekar, X Yin, K Rebolj, S Darovic, C Troakes… - Neuroscience, 2015 - Elsevier
Transactive response DNA-binding protein 43 (TDP-43) is a predominantly nuclear,
ubiquitously expressed RNA and DNA-binding protein. It recognizes and binds to UG …

Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties

ZR Grese, ACS Bastos, LD Mamede, RL French… - EMBO …, 2021 - embopress.org
TDP‐43 is an RNA‐binding protein that forms ribonucleoprotein condensates via liquid‐
liquid phase separation (LLPS) and regulates gene expression through specific RNA …

Structural insights into TDP-43 and effects of post-translational modifications

L François-Moutal, S Perez-Miller, DD Scott… - Frontiers in molecular …, 2019 - frontiersin.org
Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …

TDP‐43 N‐terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate

M Miura, F Sakaue, H Matsuno, K Morita… - FEBS …, 2023 - Wiley Online Library
Aggregation of the 43 kDa TAR DNA‐binding protein (TDP‐43) is a pathological hallmark of
amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RNA …

Importin α/β and the tug of war to keep TDP‐43 in solution: quo vadis?

SG Doll, G Cingolani - Bioessays, 2022 - Wiley Online Library
The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐
prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis …

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions

M Mompeán, V Romano, D Pantoja-Uceda… - Journal of Biological …, 2017 - ASBMB
Transactive response DNA-binding protein 43 (TDP-43) performs multiple tasks in mRNA
processing, transport, and translational regulation, but it also forms aggregates implicated in …